Análisis de la marcha y registros corticales en un modelo animal de enfermedad de Parkinson

JUAN CARLOS SORIA; PABLO YOSIN TERUYA; ALVARO GABRIEL PIZÁ; FERNANDO DANIEL FARFÁN; ANA LÍA ALBARRACÍN

Cordoba

Congreso; XXI Congreso Argentino De Bioingenieria y X Jornadas De Ingenieria Clinica; 2017

Sociedad Argentina de Bioingenería

Gait disorders are caused by many neurological and non-neurological diseases and often reflect a broad range of dysfunctions of the central and peripheral nervous systems. Parkinson?s disease (PD) is characterized by motor dysfunctions and gait disturbance. In this preliminary study we have explored dynamics aspects of the gait in a 6-OHDA rat model of PD and have quantified the gait parameters changes and its correlation with electrical parameters of movement?s cortical control. Images of the hindlimb step cycle were digitalized and quantified to be correlated with the cortical activity recorded from the hindlimb motor area. The electrocorticographic signals were correlated with gait analysis data in order to study qualitative and quantitative aspects of motor control. Significant differences were found in the maximum angle of movement and in the phase of the gait cycle in which this angle is reached. Correlations were found between movements of the gait cycle and activations in the gamma band in the primary motor cortex; the duration of the gait was greater on the injured side. This experimental protocol allows the complete study of the step cycle and correlates it with changes in motor parameters of electrocorticographic signals.