Modeling the electrical activity in myelinated nerve fibers: Towards the electrophysiological validation of neuronal bridges

NILDA MARIA DE MARCO; MARIA CECILIA SOCCI; CARLA BELÉN GOY; ANA LÍA ALBARRACÍN; CARMELO JOSÉ FELICE; FERNANDO DANIEL FARFÁN

Revista Argentina de Bioingenieria

Bioengineering Argentinian Society

Lugar: Mar del Plata; Año: 2020 vol. 4 p. 73 - 79

2591-376X

When severe injuries occur in the Central or Peripheric Nervous Tissue, this often triggers events that permanently damage the neurological function, which leads to a reduction in the patient?s quality of life. The use of bio-materials scaffolding to create bridges that re-establish the lost connections are promising, but currently, have limited applicability; and electrophysiological and biological validations demand considerable time, so it is still a field being explored by many investigators around the world. In this paper a simplified empirical model is proposed to describe the action potential generation and conduction through myelinic fibers. The model´s electrophysiological validation was performed through qualitative analysis in three experimental situations that call for action potential: a) sciatic nerve in frog, b) giant lateral axons and giant medial axon in earthworm, and c) infraorbital nerve in rats. Results evidence the proposed empirical model´s great versatility to the different evoked action potentials. The proposed model could become a valuable tool to determine the percentage of functionally connected fibers through neural bridges made of various materials.