INVESTIGADORES
MARTINEZ CALEJMAN Camila
congresos y reuniones científicas
Título:
Functional and morphological alterations in the adrenal cortex of rats with insulin resistance (IR) induced by a sucrose enriched diet
Autor/es:
MARTINEZ CALEJMAN, C; DI GRUCCIO J.M.; JAUME, F.D.; SANCHEZ R; MERCAU M.; ARIAS P.; CYMERYNG C. B.
Lugar:
Berlin
Reunión:
Congreso; 48th EASD Annual Meeting; 2012
Institución organizadora:
European association for the study of diabetes
Resumen:
Aims:-To evaluate morphological and functional changes in the adrenal cortex bythe implementation of a moderate physical exercise (E) protocol in maleWistar rats rendered insulin-resistant by means of a sucrose-rich diet (SRD).Methods:Adult young male Wistar rats received a sucrose-rich diet diet (SRD, sucrose30% w/v in drinking water) or the usual laboratory chow (C) with or withoutthe implementation of a moderate exercise protocol (E) what consisted inincreasing the time of exercise at 0.8 km/h reaching a maximum of 9 min at the9th week.Conclusions:Rats receiving the implementation of PE protocol for 9 weeks show:1) normal insulin sentitivity (glycemia,triglyceridemia, insulinemia andnormal response to ip insulin administration);2) decreased lipid filtration in the adrenal cortex (Sudan III positive lipid moiety);3) normal glucocorticoid production and no changes in the activityof local modulatory systems.The implementation of a moderate PE protocol in SRD-treated animalsnormalized insulin sensitivity and prevented the onset of morphologicaland biochemical alterations in the adrenal cortex. This protocol alsoimproved adrenal function and restored the response to acute ACTHstimulation. Taking these results, as well as previous data obtained usingan insulin-sensitizing drug, in consideration, a causal relationship betweeninsulin resistance, increased adrenocortical lipid deposition and derangedsecretory function could be hypothesized.