INVESTIGADORES
MARTINEZ CALEJMAN Camila
congresos y reuniones científicas
Título:
HEMIN TREATMENT IMPROVES GLUCOCORTICOID RESPONSE TO EXPERIMENTAL SEPSIS IN DIET-INDUCED INSULIN RESISTANT RATS
Autor/es:
CALDARERI, L.; MEISNER, F.; WISZNIEWSKI, MORENA; MARTINEZ CALEJMAN, C.; REPETTO, E.M.; CYMERYNG C. B.
Lugar:
Mar del Plata
Reunión:
Congreso; Reunion Anual de Sociedades de Biociencias; 2023
Institución organizadora:
Sociedad Argentina de Investigaciones Clinicas
Resumen:
An exacerbated response to infection, resulting in systemic inflammation, is observed during sepsis. Under these conditions, an adequate production of glucocorticoids is critical since they prevent an excessive and unbalanced immune response and for its effects on the cardiovascular system and metabolism. We have previously demonstrated the onset of adrenocortical insufficiency in rats made insulin resistant by the administration of a sucrose rich diet (SRD). An increase in oxidative stress and inflammation parameters were detected in the adrenal cortex of SRD-treated rats. The goal of the present study was to evaluate the production of GCs in SRDtreated rats in a model of sepsis by cecal ligation and puncture (CLP) and to assess the effects of hemin treatment, an inductor of an antioxidant and anti-inflammatory response, on the adrenal function. Adult male Wistar rats were fed a standard diet (controls, C) or a SRD, and then treated with/without hemin (SRDH, 15 mg/kg every 48 hours) for the last 2 weeks before surgery. At the end of the 12th week rats underwent CLP and were sacrificed 24 or 72 hours later (survival curve). Our results show higher plasma ACTH levels in the SRD-group 24 h after CLP (p