PERSONAL DE APOYO
YUNES QUARTINO Pablo Javier
artículos
Título:
Myelin structure alteration mediated by pro-inflammatory agents: effects of nitric oxide and secretory phospholipase.
Autor/es:
PABLO J. YUNES QUARTINO; GUILLERMO G. MONTICH; RAFAEL G. OLIVEIRA
Revista:
Activity Report 2011: LNLS/ Brazilian Synchroton Ligh Laboratory
Editorial:
Brazilian Synchrotron Light Laboratory
Referencias:
Lugar: Campinas, São Paulo; Año: 2012
ISSN:
1518-0204
Resumen:
Myelin is the membrane material wrapping axons in nerves.As other tissues, myelin is prone to inflammation. Severalagents are mediators of inflammation. Among them, secretoryphospholipases A2 (PLA2) and nitric oxide (NO) have beenreported to attack and/or change the myelin structure as seenby electron microscopy (EM). Nevertheless, the EM samplepreparation has been also reported to alter the myelin structureitself, causing mainly shrinking of the membrane [1]. This effectcan enhance or mask some structural modifications. Inthis report we analyze the effect of PLA2 and NO by usingSAXS as a non invasive (structure preserving) analytical technique
