INVESTIGADORES
KLER Pablo Alejandro
congresos y reuniones científicas
Título:
Numerical prototyping of USB powered microfluidic paper?based analytical devices
Autor/es:
SCHAUMBURG, FEDERICO; KLER, P.A.; BERLI, CLAUDIO L. A.; HENRY, CHARLES S.
Reunión:
Congreso; II Brazil?Argentine Microfluidics Congress; 2019
Institución organizadora:
Universidad Nacional de Córdoba
Resumen:
Microfluidic paper?based analytical devices (μPADs) allow chemical determina-tions in a user-friendly and portable format, but their main disadvantage is theirlimited applicability, mainly because the low sensitivity and the consequent lackof quantitative sensing. Several attempts to circumvent this problem have beenpresented requiring specific laboratory equipment, at the expense of usability. Si-multaneously, universal serial buses (USB) are currently available practically ev-erywhere, in electronic devices like smartphones, personal computers, and evenTV sets. Here, the concept of USB powered μPADs is presented as a fusion ofboth technologies, in order to address the low applicability of μPADs by enhancingtheir limit of detection (LOD). Additionally, USB ports are usually included inhost devices with computing power, memory, connectivity and optical sensors, ex-panding the possibilities for USB-μPADs. Moreover, an application software couldprovide guidance to the user and control mechanisms. Also, surface-mount inte-grated circuits (SMD) can be included in the paper device, providing extra capabil-ities like analogical pre-processing, digitization, on?chip data storage, and digitalprocessing. Two isotachophoretic (ITP) USB-μPADs were numerically studied,both powered by a 5 V electric potential, like the provided by any standard USBport. The first device, based on the origami approach, achieved a two?order?of?magnitude sample focusing in 15 min. The second ITP USB-μPAD constitutesa novel method for large sample processing, in which the reservoirs were movedaway from the ITP channel and capillary action was used to drive the sampleand electrolytes to the separation zone. Numerical models were implemented us-ing electroMicroTransport, an open source toolbox for the well known finite volumelibrary OpenFOAM®. Results indicate that with running times in the order of10-20 minutes, the achieved LODs are compatible with many point?of?care ap-plications and environmental analysis, where the amount of sample is a criticalfeature.