INVESTIGADORES
RAZUC Mariela Fernanda
congresos y reuniones científicas
Título:
MODELLING OF THE SPRAY DRYING PROCESS FOR RATIONAL PARTICLE DESIGN
Autor/es:
COTABARREN, IVANA M.; BERTÍN, DIEGO; M. F. RAZUC; M. V. RAMIREZ RIGO; PIÑA, JULIANA
Reunión:
Workshop; 8th International Granulation Workshop; 2017
Resumen:
Spray drying is widely applied in many industries, such as thepharmaceutical, food, detergents, polymers, to convert liquids in solidparticles. However, it still requires continuous innovation in order toprovide more sophisticated particles, which are difficult to design byusing only empirical approaches. In this context, a steady-statemathematical model for a co-current spray dryer is developed to give amore phenomenological insight in the production of inhalable particles.The model includes mass, energy and momentum balances for bothparticulate and gaseous phases. Particularly, and as a model inhalablecompound, ciprofloxacin hydrochloride (CIP) aqueous solutions arestudied. Several experimental data, obtained in a Mini-Spray Dryer B-290BÜCHI, were available. In addition, droplet size measurements werecarried out by using laser diffraction. The effect of the binary nozzleoperating conditions on the mean droplet size was analysed and acorrelation to predict the mean Sauter diameter was established. Theexperimental data are used to fit and validate the proposed model. Thevalidated model is used to perform parametric studies in order toevaluate the effect of the main process variables on the final productproperties (e.g., particle size and density, powder moisture content) andto track key powder attributes for pulmonary administration