INVESTIGADORES
RAZUC Mariela Fernanda
congresos y reuniones científicas
Título:
DATA FUSION APPLIED TO THE PHOTODEGRADATION STUDY OF CIPROFLOXACIN USING A TANDEM DETECTION SYSTEM (UV-VIS AND FLUORESCENCE) AND MULTIVARIATE CURVE RESOLUTION
Autor/es:
M. F. RAZUC, M. GARRIDO Y B.S. FERNÁNDEZ BAND
Lugar:
Córdoba, Argentina
Reunión:
Congreso; 1ª Reunión Internacional de Ciencias Farmacéuticas; 2010
Resumen:
Ciprofloxacin is a synthetic fluoroquinolone derivate which has broad-spectrum activity against many gram-negative and gram-positive pathogenic bacteria, via the inhibition of the DNA gyrase responsible of DNA preservation.   It is partially metabolized, but principally is eliminated unchanged via kidney. Consequently, a high amount of this compound is released into the environment through biological waste of humans and animals, which can cause environmental and food pollution (1). Moreover, these species may undergo changes in their chemical structure due to environmental factors, giving rise to products with different characteristics to the parent species, and whose polluting action must be taken into account. This paper presents an exploratory study of the photochemical degradation of ciprofloxacin in order to monitor the reaction throughout the time and understand the kinetic of the photodegradation under different conditions. The proposed method is a simulation of the effect of the environment as a time function, and a rapid information is obtained through Chemometric, avoiding the separation techniques commonly used to study this kind of reactions