INVESTIGADORES
CABRERIZO Franco Martin
artículos
Título:
DNA damage induced by bare and loaded Microporous Coordination Polymers from their ground and electronic excited states
Autor/es:
JUAN G. YAÑUK; MARÍA L. ALOMAR; M. MICAELA GONZALEZ; FRANCISCO SIMON; ROSA ERRA-BALSELLS; MATÍAS RAFTI *; FRANCO M. CABRERIZO *
Revista:
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: CAMBRIDGE; Año: 2015 vol. 17 p. 12462 - 12465
ISSN:
1463-9076
Resumen:
We report on interactions of cell free double-stranded DNA (dsDNA) with a selected subgroup of Microporous Coordination Polymers (MCPs). In particular, we have studied the influence of different metal ion constituents and chemically modified linkers using a set of five benzene carboxylate-based MCPs. Our results suggest that DNA moiety can be structurally modified via two different ways: by direct MCPs-dsDNA interaction and/or through photosensitized processes. The extent of the observed damage was found to be strongly dependent on the charge density of the material. The potential use of the MCPs tested as inert carriers of photosensitizers was demonstrated by analyzing the interaction between dsDNA and harmine-loaded Cr-based materials, both in the absence of light and upon UVA irradiation.