CONICET | Buscador de Institutos y Recursos Humanos

Therapeutic medical devices and systems employing electromagnetic energy are in widespread use for a diverse range of clinical applications. The biological effects of electric field interactions with cells and tissues range from nonthermal modulation of membrane transport properties to high-temperature ablative heating and are a function of the field intensity, orientation, frequency, and continuous wave versus pulsed delivery. Thus, to harness electromagnetic energy for therapeutic benefit, devices and systems need to be carefully designed so that they can provide spatio-temporal control of the desired biological response or outcome within prescribed anatomic locations.The targeted audience for this text would include advanced undergraduate and beginning graduate students with an interest in medical device and technology development, researchers andengineers in the medical device industry, and clinicians interested in technology development. Readers would benefit from prior exposure to multivariable calculus and an undergraduateengineering/physics course on electromagnetic fields. Some knowledge of anatomy/physiology may be beneficial, but is not expected of all readers. The book is organized into four sections. The first section provides readers with an overview of the fundamental physical principles of nonthermal and temperature-related effects of electromagnetic energy on biological tissue. As noted throughoutthe book, computational models play an important role in the analysis of electromagnetic-tissue interactions. A review of numerical modeling techniques pertinent to the simulation of electromagnetic fields within biological tissue is included in this section. The second section provides an overview of major ablative technologies, such as electroporation, radiofrequencyablation, and microwave ablation. Devices and systems employing these techniques are in clinical use for the treatment of a variety of indications. The chapters within this section coverthe core principles of these ablation modalities and considerations for practical technology design. The penultimate section covers subablative electromagnetic therapies, including stimu-lation of electrically excitable cells/tissues, tumor treating fields, mild hyperthermia, and applications that improve wound healing. The fourth section includes case studies from highlyexperienced researchers, describing the historical development, translation, and adaptation of technologies to meet evolving clinical needs. Also included are chapters on regulatory consid-erations and principles of clinical trial design for emerging electromagnetic technologies.A companion website for this book will be maintained. Example computational models to accompany some of the technologies covered in this book are provided. We intend forthis website to remain dynamic and aim to post example lab exercises and protocols. Readers interested in contributing to this resource are encouraged to contact the editors.We are highly appreciative of the contributions from the expert authors. Their careful attention to detail in assembling and presentation of the material is gratefully acknowledged. Notably,much of this book was developed over the course of a global pandemic, during a time of several unexpected additional commitments, and great stress and uncertainty. We very much appreciate the authors? dedication to providing these chapters and contributions for the timely preparation of this book. We also offer our thanks to Rafael Trombaco, our Editorial Project Man-ager, for his tremendous support and patience in seeing this project through to completion; thank you, Rafael! In a book of this extent, there may inevitably be a few inadvertent errors. We would welcome communication from readers bringing these to our attention so that we can rectify them. Any kudos are received with gratitude on behalf of all the authors.

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