INDUCTION OF THE TOLEROGENIC DENDRITIC CELLS DC-10 INTO THE DECIDUA: THE CONTRIBUTION OF TROPHOBLAST CELLS

ANA SCHAFIR; VANESA HAUK; BRENDA LARA; LAURA FERNÁNDEZ; JORGELINA BLEJER; ALEJANDRA GRASSI BASSINO; ESTEBAN GRASSO; CLAUDIA PÉREZ LEIRÓS; ROSANNA RAMHORST; SOLEDAD GORI

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencias SAIC-SAI 2022; 2022

SAI-SAIC-SAFIS

Immunomodulation and tolerance induction are strictly requiredduring pregnancy. A novel and distinctive subset of HLA-G+ tolerogenic dendritic cell, DC-10, was found increased in first-trimesterdecidua. Recently, we showed that decidualized cells can conditionmaternal monocytes to DC-10 profile during the pre-implantation period. Here we aimed to explore the potential contribution of DC-10in first-trimester decidua and the impact of trophoblast cells in itsinduction. First, we performed an integrated bioinformatic analysissince public array-based data. We found 212 up-regulated genesin DC-10 relative to mature and immature DC (p