PERSONAL DE APOYO
ADROVER Ezequiela
artículos
Título:
Prenatal maternal restraint stress exposure alters the reproductive hormone profile and testis development of the rat male offspring
Autor/es:
PALLARÉS ME; ADROVER E; BAIER CJ; BOURGUIGNON NS; MONTELEONE MC; BROCCO MA; GONZÁLEZ-CALVAR SI; ANTONELLI MC
Revista:
STRESS
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Londres; Año: 2013 p. 429 - 440
ISSN:
1025-3890
Resumen:
Several studies have demonstrated that the presence of stressors during pregnancy induces adverse effects on the neuroendocrine system of theoffspring later in life. In the present work, we investigated the effects of early programming on the male reproductive system, employing a prenatalstress (PS) paradigm. This study found that when pregnant dams were placed in a plastic restrainer three times a day during the last week of pregnancy, the offspring showed reduced anogenital distance and delayed testicular descent. Serum luteinising hormone (LH) and follicle-stimulatinghormone (FSH) levels were decreased at postnatal day (PND) 28 and testosterone was decreased at PND 75. Increased testosterone plus dihydrotestosterone (T + DHT) concentrations correlated with increased testicular 5α Reductase-1 (5αR-1) mRNA expression at PND 28. Moreover, PS accelerated spermatogenesis at PND 35 and 60, and increased mean seminiferous tubule diameter in pubertal offspring and reduced Leydig cell number was observed at PND 35 and 60. PS offspring had increased androgen receptor (AR) mRNA level at PND 28, and at PND 35 had increased the numbers of Sertoli cells immunopositive for AR. Overall, the results confirm that stress during gestation can induce long-term effects on the maleoffspring reproductive system. Of particular interest is the pre-pubertal imbalance of circulating hormones that probably trigger accelerated testiculardevelopment, followed by an increase in total androgens and a decrease in testosterone concentration during adulthood. Exposure to an unfavourable intrauterine environment might prepare for harsh external conditions by triggering early puberty, increasing reproductive potential.