INVESTIGADORES
MUSCIA Gisela Celeste
congresos y reuniones científicas
Título:
Synthesis and Chemotherapic Activity of Quinoline Derivatives.
Autor/es:
S. E. ASÍS; M. BOLLINI; J. P. CARNEVALE; G. C. MUSCIA; S. RENOU; A. M. BRUNO
Lugar:
Rio de Janeiro, Brasil
Reunión:
Simposio; 2nd. Brazilian Symposium on Medicinal Chemistry; 2004
Institución organizadora:
Bazilian Chemical Society, Division of Medicinal Chemistry
Resumen:
It is known that there is an urgent need for new drugs for chemotherapy of several parasitic diseases such as Malaria, Human African trypanosomiasis, Chagas disease and Leishmaniasis. Furthermore, the recent resurgence of tuberculosis warrants the development of new therapeutic strategies for the effective control of it. In this way, a large substituted quinoline series as potential anti-tuberculosis compounds have been reported recently. To carry out alternative drugs, novel quinoline and quinolin-2-one derivatives structurally related to antimalarial agents such as chloroquine and amodiaquine, have been synthesized. The biological evaluations of these quinoline and quinolone series were performed at WHO (Switzerland) and TAACF (USA) as antiparasitic and anti-tuberculosis drugs, respectively. Two compounds showed some relatively specific activity against P. falciparum, although the activity was not strong. One compound with an urea moiety had some non-specific activity and the remaining compounds were either inactive or showed only poor activity.