In vitro activity 2-styryl-4-quinolincarboxilic acids against Trypanosoma cruzi

A. LUCZYWO; BOCCIA T; MUSCIA G; SILVER A; ASIS S

CABA

Encuentro; DRUG DISCOVERY FOR NEGLECTED DISEASES INTERNATIONAL CONGRESS 2018; 2018

DDnDi

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is potentially fatal. It is estimated that thereare between 6 and 7 million infected people in the world [1]. Existing therapies for this neglected tropical disease havesevere side effects, complex and prolonged dosing regimens, high toxicity, and emerging resistance. Therefore, there isa growing need to find alternative treatments.Our research group has reported that 2-substituted quinolines [2] and especially 2-arylvinyl (or styryl) derivatives isolatedfrom plants [3] or prepared by synthesis, exhibited a broad spectrum of biological activities such as leishmanicide andtrypanocide. In order to increase the antichagasic activity, we have prepared a series of 2-arylvinyl-4-quinolinecarboxylicacids.