INVESTIGADORES
DELFINO Cecilia Maria
congresos y reuniones científicas
Título:
HLA association with HTLV-1/2 infection in different populations of Argentina
Autor/es:
CAROLINA BERINI, MARIA E EIRIN, RICHARD MALAN, ROGELIO ESPEJO, CECILIA DELFINO, GRACIELA THEILER, MIRNA BIGLIONE
Lugar:
Leuven and Gembloux
Reunión:
Congreso; 15th International Conference on Human Retroviruses: HTLV and Related Viruses; 2011
Resumen:
Introduction
HLA class 1 alleles HLA-A*24,*26 and HLA-B*07,*61 were associated to susceptibility for HTLV-1 infection. While HLA-A*02 was associated to protection to HAM/TSP, HLA-B*07 was associated to susceptibility for disease. Alleles HLA-A*02 and HLA-B*27,*40,*48 were described in aboriginal populations of Russia genetically related to Andean aborigines. This study analyzed the association of HLA with susceptibility to HTLV-1 or -2.
infections.
Materials and methods
60 negative samples from aboriginal populations, 23
HTLV-1 samples (12 from blood donors (BD), 11 from
Kollas) and 32 HTLV-2 positive samples from Buenos
Aires residents were analyzed. HTLV-2 positive individuals
and BD were predominantly of Caucasian origin.
HLA class 1 (A, B) characterization was performed on
genomic DNA using the PCR-SSO technique and chemiluminescence.
Exons 2 and 3 of HLA-A and B genes
were amplified.
Results
The HLA-A*02 allele was frequently observed in all
groups, being significantly higher among HTLV-1+, and
among HTLV-1+ Kollas compared to non-infected ones
(p=0.03). HLA-A*31 and *68 were significantly more frequent
among negative individuals. HLA-B*07 was higher
in HTLV-2+ individuals. HLA-B*35 was higher in
HTLV-1 compared to HTLV-2 and in HTLV-1 infected
Kollas compared to HTLV-1 infected Caucasians but similar to negative Kollas. HLA-B*40 was higher in
negative individuals compared to HTLV-2+ ones.
Discussion
These data suggest a possible association of HLA-A*02
to susceptibility to infection while HLA-A*31 and *68
may have a possible protective effect against HTLV-1
natural infection. HLA-B*07 might increase HTLV-2
susceptibility to infection. These results show that the
allele HLA-B*35 is associated to ethnic groups while the
presence of alleles HLA-A*02 and HLA-B*07 may
increase susceptibility to HTLV-1 and HTLV-2 infection,
respectively. Our observations support that the
HLA haplotype modulates the susceptibility to HTLV-1/
2 infection.