INVESTIGADORES
FERNANDEZ Maria Celia
artículos
Título:
New insights into pheochromocytoma biology: the role of the insulin- like growth factor 1 (IGF1) system
Autor/es:
PATRICIA PENNISI; FERNÁNDEZ, MA. CELIA; AYELEN MARTIN
Revista:
Pediatric endocrinology reviews
Editorial:
YS Medical Media Ltd
Referencias:
Año: 2020
ISSN:
1565-4753
Resumen:
ABSTRACTPheochromocytomas/paragangliomas (PCCs/PGLs) are rare neuroendocrine tumors,developed from chromaffin cells derived from the neural crest. From a genetic point ofview PCCs/PGLs are divided as sporadic cases, and inherited cases as part ofhereditary (familial) syndromes. While the majority is benign, up to 26% of PCCs/PGLswill undergo malignant transformation. Validated prognostic pathological parameters formalignant PCCs/PGLs are still lacking. Signaling that follows the interactions betweenIGFs and their receptor/s in tumor cells received extensive attention when investigatingthe role of IGF1R in cancer. Increased IGF1R expression has been shown duringprogression to metastatic phenotypes and associated with worse prognosis in severaltypes of cancer. In this review we provide evidence supporting a role for the IGFssystem on PCC/PGL tumor biology and malignant behavior, endocrine actions tosustain tumor phenotype as well as heterotypic interaction´s regulation by IGF1,encouraging further research for targeted therapeutic options for these tumors.