INVESTIGADORES
FERNANDEZ Ariel
artículos
Título:
Communication: Chemical functionality of interfacial water enveloping nanoscale structural defects in proteins
Autor/es:
ARIEL FERNANDEZ
Revista:
JOURNAL OF CHEMICAL PHYSICS
Editorial:
AMER INST PHYSICS
Referencias:
Lugar: New York; Año: 2014 vol. 140 p. 221102 - 221102
ISSN:
0021-9606
Resumen:
Building upon a non-Debye multiscale treatment of water dielectrics, this work reveals the biochemical role of interfacial water enveloping nanoscale structural defects in soluble proteins, asserting its role as a chemical base. This quasi-reactant status is already implied by the significant concentration of structural defects in the vicinity of an enzymatically active site, delineating their role as promoters or enhancers of catalytic activity. © 2014 AIP Publishing LLC. [http://dx.doi.org/10.1063/1.4882895]
