CONICET | Buscador de Institutos y Recursos Humanos

One of the most important impediments that therapeutic drugs have is their arrival at the biological target (physical barriers, dilution, environmental stability, etc). In this sense, hydrogels have emerged as a potential candidate to compete with many of the existing materials associated with drug delivery. Hydrogels are three-dimensional networks with high water absorption, capable of being loaded with different compounds and then release them in a specific condition. The aim of the present work is to characterize the conditions in which albumin could aggregate to produce hydrophilic nanomaterials with high loading capacity and good releasing profile in biological conditions. Different aggregation conditions were explored and the hydrogels obtained were characterized by using fluorescence and infrarred spectroscopy as well as swelling ratio (SR) with H2Od or DMEM culture media. Those with best SR where probed for loading/releasing capacity with different dyes and the most efficient were tested in vivo to study biocompatibility. To do this, we used a standard murine model; hydrogels were injected in the peritoneal cavity or orally administered. The inflammatory response was tested according Maldonado Galdeano 2011(1). The low immune response indicate that the selected preparation could be able to be functionalized with specific antibodies to reach different targets and this novel nanomaterial could represent a potential and promising system for drug delivery

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