The oral stimulation of Lactobacillus casei enhance the IgA cycle

DE MORENO DE LEBLANC, C. MALDONADO GALDEANO, S. CHAVES Y G. PERDIGÓN.

Tafi del Valle. Tucuman

Jornada; XX Jornadas Cientificas de la Asociacion de Biologia de Tucumán; 2003

Sociedad de Biologia de Tucuman

Lactic Acid Bacteria (LAB) used in fermented product enter the gastrointestinal tract and interact with the gut associated lymphoid tissue increasing antibodies (principally secretory IgA) production. IgA secreting cells can repopulate not only the lamina propria but also they can the other distant sites such bronchus, urogenital tract and mammary glands. That is known as IgA cycle. Aims: To study the IgA cycle stimulation by oral administration of LAB. Material and Methods: Balb/c mice were fed with L. casei CRL431 during 2, 5 or 7 days. At the end of feeding period, the mice were killed and the small intestine, the lung and the mammary glands were removed. IgA + cells were counted in tissue slices using indirect immunofluorescence. Results: IgA+ cells increased in the intestine samples taken after 7 days of LAB feeding. In mammary and lung tissues, IgA+ cells increased after five days of feeding. Conclusion: L. casei showed stimulated the immune system in the ntestine and also stimulated the immune response in other distant sites. These results allow us to propose that the oral administration of this LAB can act as oral adjuvant, protecting not only the intestine but also other tissues such as bronchus and mammary gland by increasing of IgA cycle.