INVESTIGADORES
GONZALEZ SANCHEZ WUSENER Ana Elena
artículos
Título:
3D printed poly(hydroxybutyrate-co-hydroxyvalerate)—45S5 bioactive glass composite resorbable scaffolds suitable for bone regeneration
Autor/es:
ARÁOZ, BEATRIZ; KARAKAYA, EMINE; GONZÁLEZ WUSENER, ANA; DETSCH, RAINER; BIZZOTTO, JUAN; GUERON, GERALDINE; BOCCACCINI, ALDO R.; HERMIDA, ÉLIDA B.
Revista:
JOURNAL OF MATERIALS RESEARCH
Editorial:
MATERIALS RESEARCH SOC
Referencias:
Año: 2021
ISSN:
0884-2914
Resumen:
3D printing for tissue engineering requires biomaterials with mechanical and biological propertiessuitable for both tissue regeneration and the printing process. A filament made of poly(hydroxybutyrateco-hydroxyvalerate) (PHBV) combined with 45S5 Bioglass (BG) was used to print 3D scaffolds by fused deposition modeling (FDM). Chemical treatment of BG particles with chlorotrimethylsilane (CTMS) improved the ductility of the extruded filaments and allowed excellent printability. Controlling the printing parameter infill density (I%), from 20 to 90%, scaffolds were obtained with interconnected pores and channel sizes in the 100?800 μm range and exhibiting tensile modulus from 0.25 to 1.36 GPa. PHBV + BG scaffolds and PHBV scaffolds coated with CTMS treated BG particles, as a model of a rough and biologically active coating, showed no cytotoxic effects, and cells preferred the scaffolds containing BG in terms of cell spreading. Mechanical and biological properties of the scaffolds were similar to those of the extracellular matrix (ECM) of trabecular bone.