GONZALEZ SANCHEZ WUSENER Ana Elena
Protein tyrosine phosphatase PTP1B in cell adhesion and migration
CARLOS O. ARREGUI; ÁNGELA GONZÁLEZ; JUAN E. BURDISSO; ANA E. GONZÁLEZ WUSENER
Cell Adhesion & Migration
Año: 2013 p. 418 - 423
Cell migration requires a highly coordinated interplay between specialized plasma membrane adhesion complexes and the cytoskeleton. Protein phosphorylation/dephosphorylation modifications regulate many aspects of the integrin-cytoskeleton interdependence,including their coupling, dynamics,and organization to support cell movement. The endoplasmic reticulum-bound protein tyrosine phosphatase PTP1B has been implicated as a regulator of cell adhesion and migration. Recent results from our laboratory shed light on potential mechanisms, such as Src/FAK signaling through Rho GTPases and integrin-cytoskeletal coupling.