USEFULNESS OF ANALYSIS OF MINERAL METABOLISM AND VASCULAR CALCIFICATION IN PATIENTS WHO WILL UNDERGO A KIDNEY TRANSPLANT

LEÓN LUIS, MINUÉ ELENA, PIZARRO CARLOS, OLGA GUARDIA, ANCIETA NELA, PERCISCHINI ALFREDO, CHULUYAN H. EDUARDO, MARÍA DEL CARMEN RIAL, CASADEI DOMINGO

Congreso; World Transplant Congress; 2014

It is well known that patients that will undergo kidney transplantation have alterations in phosphocalcic metabolism and vascular calcifications, due to hemodialysis and the etiology of the underlying disease. The aim of this preliminary study was to survey the state of mineral metabolism and vascular calcification score in patients who were to undergo a kidney transplant and to assess whether these defects had impact in early kidney function. In this prospective study 100 patients were analyzed (37 females and 63 males) with a mean age of 50 ± 17. From them, 82 were on hemodialysis, 11 on chronic peritoneal dialysis and 7 pre-emptive. We measured serum calcium and phosphate, alkaline phosphatase (ALP), intact parathyroid hormone (iPTH), 25-hydroxy-vitamine D (25(OH)D). Simple vascular calcifications and abdominal aortic (AA) wall calcifications were evaluated on plain radiographic films of pelvis (P) and hands (H) (Andragao et al., Nephrol Dial Transplant. 2004 Jun; 19(6):1480-8) and lateral lumbar films (Kauppila at el. Atherosclerosis. 1997 Jul 25; 132(2):245-50.), respectively. We found a direct correlation between the age of the patient and vascular calcificactions (P, p=0.014; H, p=0.008; AA, p=0, 0001). We also found and inverse correlation between the age and ALP (p=0.026). A direct strong correlations were observed between the time on hemodialysis and both, vascular calcifications (p