INVESTIGADORES
MARRASSINI Carla
congresos y reuniones científicas
Título:
Actividad analgésica y antiiflamatoria del extracto etanólico de Urtica urens
Autor/es:
MARRASSINI CARLA; ACEVEDO CRISTINA; MIÑO JORGE; FERRARO GRACIELA; GORZALCZANY SUSANA
Lugar:
Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Tandil.
Reunión:
Otro; Cuadragésima Reunión Anual de SAFE (Asociación Argentina de Farmacología Experimental); 2008
Institución organizadora:
Asociación Argentina de Farmacología Experimental (SAFE)
Resumen:
Urtica urens L. (Uu) belongs to the Urticaceae family and it is known with the common names of "ortiga", "ortiga crespa", "ortiga chica". This is a native herb widely distributed in South America and also in Europe, Africa, Asia and Australia. In South America, is widely used in popular medicine as diuretic, antirheumatic and for muscular pain. For this study, the dried aerial parts were ground to a fine powder and were extracted by maceration with 80% ethanol at room temperature for 24 hours. The extract of Uu was evaluated for antinociceptive activity using writhing, formalin and hot-plate tests in mice. A dose-related antinociceptive response was obtained in the writhing test at doses between 10 - 500 mg/kg i.p. (percentage of inhibition 59 to 96%). The extract also inhibited the second phase of formalin test (77 %) at dose of 100 mg/kg i.p. Furthermore, no significant effect was obtained in the hot-plate test. The anti-inflammatory activity was analyzed with the carrageenan-induced paw edema in rats at doses of 100 and 300 mg/kg i.p. A significant antiedematogenic effect was obtained at doses of 300 mg/kg (42 % of inhibition); no effect was seen in the ear edema induced by 12-O-tetradecanoylphorbol-13 acetate (TPA) in mice. These results indicate that Uu has antinociceptive and antiinflammatory activities that could be support the folk medicinal use of the plant.