congresos y reuniones científicas
Urtica circularis: antinociceptive and antiinflammatory effects on experimental models
Rosario, Argentina
Otro; XLI Reunión Anual de la Sociedad Argentina de Farmacología Experimental; 2009
Institución organizadora:
Urtica circularis (Hicken) Sorarú (Uc) belongs to the Urticaceae family and is known with the common names of "ortiga", "ortiga crespa", "caá poropí", and "urtiginha miúda". This is an Argentinean native herb and is widely distributed in Paraguay, Uruguay and Brazil. The whole plant is covered with stinging hairs and it has long been used for self-treatment of arthritic pain. Moreover, several species of Urtica are used in the folk medicine as antipyretic and anti-inflammatory agents and for pain relief. In addition, nettles are considered to be a very nutritious food they are easily digested and are high in minerals (especially iron), vitamin C and pro-vitamin A. For this study, Uc was collected in Estancia "La Merced", Saladas Department, 12th Route, Corrientes, Argentina. The dried aerial parts were ground to a fine powder; 200 g of this material were extracted seven times by maceration with 80% ethanol at room temperature for 24 hours. The ethanolic extracts were pooled before experimentation. The antinociceptive activity of Uc was analyzed the writhing, formalin and hot-plate tests in mice. A dose-related antinociceptive response was obtained in the writhing test at doses between 30 and 500 mg/kg i.p. and 100 mg/kg p.o. (inhibition: between 52% and 96%). The extract also inhibited the formalin test?s second phase at doses of 30 mg/kg i.p and 250 mg/kg p.o. (inhibition: 78% and 88%, respectively). Furthermore, no significant effect was obtained in the hot-plate test. The anti-inflammatory activity was analyzed with the carrageenan-induced paw edema in rats at doses of 100 and 300 mg/kg i.p. A significant antiedematogenic effect was obtained at doses of 300 mg/kg (40% of inhibition). But no effect was seen in the ear edema test induced by 12-O-tetradecanoylphorbol-13 acetate (TPA) in mice. On the other hand Uc didn't induce gastric ulceration at a dose of 100 mg/kg i.p., but at 300 mg/kg, it produced a slight gastric lesion (petechial points), which was lesser than the one produced by indomethacin 10 mg/kg i.p. These results indicate that Uc have analgesic and anti-inflammatory activities that could support the folk medicinal use of the plant.