Chracterization of the Y-chromosome of a New World Adam

BAILLIET G; BRAVI CM; CATANESI C; MARTÍNEZ-MARIGNAC VL; VIDAL-RIOJA LB; HERRERA RJ; LÓPEZ CAMELO JS; BIANCHI NO

Journal Genetics Molecular Biology

CEPS

Lugar: Taipei, Taiwan; Año: 1998 vol. 9 p. 101 - 112

1016-6203

We analysed the allelic polymorphisms in seven Y-specific microsatellite loci and a Y-specific alphoid system with 27 variants (ƒ¿hl-XXVII). A total of 53 Y chromosomes carrying the DYS199T allele and belonging to Amerindian (51) and Na-Dene (2) linguistic groups were studied. The information gathered allowed us to identify the ancestral founder haplotype (OA) and to recognize 7 derived haplogroups diverging from OA by 1-7 mutational steps. The OA haplotype was the most frequent one and had the following allele constitution: DSY199T; ƒ¿hII; DYS19/13; DYS389A/10; DYS389b/27; DYS390/24; DYS391/10; DYS392/14, DYS393/13 (microsatellite alleles are indicated as number of repeats). All native Americans had the DYS199T allele and the ƒ¿hII form. Since there are no indications of recurrency for the DYS199C„T transition, we conclude that all DYS199T haplotypes derive from a single individual in which the C„T mutation occurred for the first time; we call this individual a gNew World Adamh. We analysed the Y-specific microsatellite mutation rate in 1743 father-son transmissions and we pooled our data with equivalent information in literature to obtain an average rate of 0.0018. We could estimate that the OA haplotype has an average age of 33,750 years (minimum 20,250 and maximum 88,050 years). DYS199T allele is found in 85-90% of Amerindian chromosomes indicating that OA haplotype is the most prevalent or perhaps the only founder paternal lineage of New World aborigines.