Origin of YAP+ lineages of the human Y-chromosome

BRAVI CM; BAILLIET G; MARTÍNEZ-MARIGNAC VL; BIANCHI NO

AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Wiley-Liss, Inc.

Lugar: New York, USA; Año: 2000 vol. 112 p. 149 - 158

0002-9483

We screened a total of 841 Y-chromosomes representing 36 human populations of wide geographical distribution for the presence of a Y-specific Alu insert (YAP1 chromosomes). The Alu element was found in 77 cases. We tested 5 biallelic and 8 polyallelic markers in 70 out of the 77 YAP1 chromosomes. We could identify the existence of a hierarchical and chronological structuring of ancestral and derived YAP1 lineages, giving rise to 4 haplogroups, 14 subhaplogroups and 60 haplotypes. Moreover, we propose a monophyletic origin for each one of the YAP1 lineages. Out-of-Africa and out-of-Asia models have been suggested to explain the origin and evolution of ancestral and derived YAP1 elements. We analyze the evidence supporting these two hypotheses, and we conclude that the information available does not allow one to decide between the out-of-Asia or out-of-Africa models. Alu insert (YAP1 chromosomes). The Alu element was found in 77 cases. We tested 5 biallelic and 8 polyallelic markers in 70 out of the 77 YAP1 chromosomes. We could identify the existence of a hierarchical and chronological structuring of ancestral and derived YAP1 lineages, giving rise to 4 haplogroups, 14 subhaplogroups and 60 haplotypes. Moreover, we propose a monophyletic origin for each one of the YAP1 lineages. Out-of-Africa and out-of-Asia models have been suggested to explain the origin and evolution of ancestral and derived YAP1 elements. We analyze the evidence supporting these two hypotheses, and we conclude that the information available does not allow one to decide between the out-of-Asia or out-of-Africa models.