SLPI in the perfusion solution helps to identify graft quality in kidney transplants

AMBROSI, NELLA G.; CARO, FIORELLA Y.; OSELLA, FRANCISCO; ALVAREZ, LEONARDO DIAZ; SÁNCHEZ, FRANCISCO; TONIOLO, FERNANDA; GUERRIERI, DIEGO; INCARDONA, CLAUDIO; CASADEI, DOMINGO; CHULUYAN, EDUARDO

BIOMARKERS IN MEDICINE

FUTURE MEDICINE LTD

Año: 2019

1752-0363

Aim: It is important to find biomarkers that identify the graft quality in kidney transplantation. Results & methodology: The level of SLPI in the cold preservation solution was used as a marker to predict early kidney graft function after transplantation. Before transplantation, kidneys were washed and SLPI was measured in the discarded solution. A retrospective analysis showed that patients with delayed graft function or rejection episodes in post-trasplant, had higher SLPI concentrations in the perfusion solution than patients without delayed graft function or rejections. Furthermore, SLPI could discriminate between patients with better or worse estimated glomerular filtration rate among low-risk patients (kidney donor profile index