INVESTIGADORES
SOBA Alejandro
congresos y reuniones científicas
Título:
Electric field effects in tumors: in vitro and in silico modeling
Autor/es:
COLOMBO; DENGRA; FERNÁNDEZ SLEZAK; GONZALEZ; MARSHALL; MOCSKOS; MOLINA; RISK; SOBA; SUAREZ; TURJANSKI
Lugar:
Buenos Aires
Reunión:
Congreso; ISEHD 2006; 2006
Resumen:
The electrochemical treatment (EChT) of tumors consists in the passage of a direct electric current through electrodes inserted locally in the tissue, which causes its necrosis. The extreme pH changes induced had been proposed as the main tumor destruction mechanism. Here we study ion transport during the EChT through in vitro modeling with agar and collagen gels, and in silico or numerical modeling using the one-dimensional Nernst-Planck and Poisson equations describing ion transport in a four-ion electrolyte under constant current conditions. Experiments and simulations reveal that, under EChT modeling, an initial condition with almost neutral pH concentration becomes extremely alkaline and acid at the cathode and anode, respectively, and from there the pH concentration rapidly turns to its neutral values into the periphery. The pH front tracking scales in time close to tt 1/2, indicating a diffusion-controlled process. These results could have significant implications in a future design of optimal operative conditions and dose planning of EChT therapy./2, indicating a diffusion-controlled process. These results could have significant implications in a future design of optimal operative conditions and dose planning of EChT therapy.