Epigenetic Landscape and miRNA Involvement During Neural Crest Development.

STROBL MAZZULLA, P.H.; MARINI, M.; BUZZI, A. L.

DEVELOPMENTAL DYNAMICS

WILEY-LISS, DIV JOHN WILEY & SONS INC

Lugar: New York; Año: 2012

1058-8388

The neural crest (NC) is a multipotent, migratory cell population that arises from the dorsal neural fold of vertebrate embryos. NC cells migrate extensively and differentiate into a variety of tissues, including melanocytes, bone and cartilage of the craniofacial skeleton, peripheral and enteric neurons, glia, smooth muscle and endocrine cells. For several years, the gene regulatory network that orchestrates NC cells development has been extensively studied. However, we have recently begun to understand that epigenetic and post-transcriptional regulation, such as miRNAs, plays important roles in NC development. In this review, we focused on some of the most recent findings on chromatin-dependent mechanisms and miRNAs regulation during vertebrate NC cells development.