INVESTIGADORES
KAMENETZKY Laura
congresos y reuniones científicas
Título:
Whole genome analysis of helminthic parasites
Autor/es:
KAMENETZKY, L.
Reunión:
Encuentro; Segundo Programa Franco-Argentino en Biociencias: ?Big Data, Genómica y Salud Humana?; 2018
Resumen:
Whole genome sequences provideextraordinary information about any organism. Despite the globalimpact, both medically and economically of helminthic infections these parasite genomes are underrepresented in genomicdatabases. The first genome sequence from a parasitic helminth waspublished in 2007, since then only ~200 genomes areavailable most of them being draft assemblies. Our work centers in completegenome sequencing of neglected parasitic helminthes. Recently, we sequenced thecomplete genome of Echinococcuscanadensis (G7) and compared it with Echinococcus multilocularis and Echinococcus granulosus(G1) genomes. Comparative genomics allowed us toconfirm the status of E. canadensis (G7)as a separate species and demonstrated a high nucleotide sequences divergencein relation to E. granulosus (G1).This result was unexpected since both parasite species are considered to belongto the same species complex: Echinococcusgranulosus sensu lato. At present there is no unequivocal taxonomicclassification of Echinococcusspecies therefore additional Cestode genomes are needed to be sequenced. Inthis regard, we sequence Echinococcusoligarthrus genome to  and reconstructEchinococcus phylogeny by wholegenome SNPs analysis. Also, in an international consortium we are sequencingEchinococcusvogeli and re sequencing Echinococcus spp. form several host andgeographical regions. Moreover, we are also sequencing the genome of the giantkidney worm Dioctophyma renale, the largest parasitic nematode ofterrestrial vertebrates described so far which affects domestic animals,endangered wildlife, and humans. With this foundational project we aimed toobtain complete information about Clade I nematodes which is the least studiedgroup of this phylum.