INVESTIGADORES
JAHN Graciela Alma
artículos
Título:
Alterations in the lipid content are associated to modifications in hormone secretion of pituitary gland in cadmium treated rats.
Autor/es:
CALDERONI AM,; OLIVEROS L; JAHN G; ANTON R; GIMÉNEZ MS
Revista:
BIOMETALS
Editorial:
Kluwer Academic Publishers
Referencias:
Año: 2005 vol. 18 p. 213 - 220
ISSN:
0966-0844
Resumen:
The present study was undertaken to assess whether chronic exposition to cadmium (Cd, 15 ppm for 2 months) through drinking water may affect the lipid contents in the pituitary anterior lobe (PAL) of adult male Wistar rats. As compared to metal non-exposed controls, PALs exposed to cadmium showed an increase in total phospholipid contents, which was associated to an increase of the incorporation of [1-14C]-methyl choline into phosphatidylcholine and of [U-14C]-glucose into total phospholipids. The incorporation of [1-14C]-methyl choline into sphingomyelin was not changed. Incorporation of [1-14C]-acetate into total fatty acids also increased but incorporation of [1-14C]-acetate into cholesterol did not change. The activity of phospholipase D decreased both in PALs from Cd exposed rats and in PAL dispersed cells treated with Cd in the culture medium from Cd non exposed rats. In PALS from Cd exposed rats, a decrease of serum prolactin and growth hormone concentrations was determined. The results show that cadmium modifies the lipid contents of pituitary gland and this may directly or indirectly alter the prolactin and growth hormone secretions.