Model for deconstruction of the non-carcinogenic risk of metals and metalloids in food.

DEMICHELIS S.O; P.M. DEMETRIO; J.S. FUCHS; D. NASSINI,; F. ÁLVAREZ; A.E. BOHÉ,; L.N. CHIODI BOUDET,; F.CORA JOFRE,; L. FERNÁNDEZ, ; L.P. FERNÁNDEZ,; S. MEDICI, ; S. MISCORIA; M. PRIMOST, ; M.B. ROMERO,; M. SAVIO, ; VOLPEDO, A

Santiago de Chile

Congreso; SETAC; 2022

SETAC

Heavy metals and metalloids are persistent and bioaccumulative pollutants, therefore, they are present in food and are toxic to human. To determine what are the allowable intake values of an element for a given human population, dietary habits constitute an issue to solve; in addition, it is necessary to establish national regulatory standards. In order to assess the acceptable limit values of element concentration for a given food, a non-traditional risk model has been developed, based on the reference dose as admissible daily intake for each contaminant, following a classical non-carcinogenic risk model in a backward sense. A characteristic annual dish must be proposed from the intake/year per capita, as a percentage of the total meal for each food item. Data included in the proposed dish are obtained from the national domestic consumption. Different exposure pathways have to be considered based on the human food web. Furthermore, it is necessary to characterize the diet throughout different regions in the country under assessment. Published element concentrations from different food chain are assessed and integrated in a unique annual dish, including wild animals (terrestrial and aquatic), farming animals (aquaculture, poultry and livestock), animal products, crops, processed grains and beverages. According to available data, different distribution models are suggested to be applied to assess the concentration of elements in food. Metal portion absorbed by each food web level is estimated from absorption factors published. The total annual intake of one element is calculated from the relative contribution of each diet item, considering each food chain when it is necessary. An estimation of non-carcinogenic risk could be done according to weight, age, and sex. This model could be used toSETAC Latin America 14th Biennial Meeting Abstract Book 41establish an acceptable maximum intake from a specific food origin, according to their element content. Besides, it is a preliminary attempt to build a model to integrate human health risks from different pollutants associated with ingesta;[1] [2] with the aim of reducing [3] uncertainties and increasing strengths, turning as a utility tool to decision makers to elaborate of guidelines values. The methodology presented was developed by the RSA-CONICET research group, contributing to establish food guidelines for metals and metalloids in the productive chain.