INVESTIGADORES
AYBAR Manuel Javier
artículos
Título:
Functional analysis of hairy genes in Xenopus neural crest initial specification and cell migration
Autor/es:
GUILLERMO VEGA LÓPEZ; MARCELA BONANO; CELESTE TRÍBULO; JUAN P. FERNÁNDEZ; TRISTÁN H. AGUERO; MANUEL J. AYBAR
Revista:
DEVELOPMENTAL DYNAMICS
Editorial:
WILEY-LISS, DIV JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2015
ISSN:
1058-8388
Resumen:
Background: Neural crest formation is one of the fundamental processes in the early stages of embryonic development in vertebrates. This transient and multipotent embryonic cell population is able to generate a variety of tissues and cell types in the adult body. hairy genes are transcription factors that contain a bHLH domain which binds to DNA. In Xenopus three hairy genes are known: hairy1, hairy2a and hairy2b. The requirement of hairy genes was explored in early neural crest development although the late requirements of these genes during neural crest maintenance, migration and derivatives formation are still unknown. Results: In this work we extended the analysis of Xenopus hairy genes expression patterns and described new domains of expression. Functional analysis showed that hairy genes are required for the induction and migration of the neural crest and for the control of apoptosis. Moreover, we showed that hairy genes function as transcriptional repressors and that they are down-regulated by BMP-Smad signaling and positively regulated by the Notch/Delta-Su(h) pathway. Conclusion: Our results indicate that hairy genes have a functional equivalence between them and that they are required for multiple processes during neural crest development.