CONICET | Buscador de Institutos y Recursos Humanos

When severe injuries occur in the Central or Peripheric Nervous Tissue, this often triggers events that permanently damage the neurological function, which leads to a reduction in the patient?s quality of life. The use of bio-materials scaffolding to create bridges that re-establish the lost connections are promising, but currently, have limited applicability; and electrophysiological and biological validations demand considerable time, so it is still a field being explored by many investigators around the world. In this paper a simplified empirical model is proposed to describe the action potential generation and conduction through myelinic fibers. The model´s electrophysiological validation was performed through qualitative analysis in three experimental situations that call for action potential: a) sciatic nerve in frog, b) giant lateral axons and giant medial axon in earthworm, and c) infraorbital nerve in rats. Results evidence the proposed empirical model´s great versatility to the different evoked action potentials. The proposed model could become a valuable tool to determine the percentage of functionally connected fibers through neural bridges made of various materials.

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