DNA damage induced by photoexcited bare and loaded Microporous Coordination Polymers

MATÍAS RAFTI; GABRIEL YAÑUK; M. MICAELA GONZÁLEZ; M.LIS ALOMAR; FRANCO M. CABRERIZO

Chascomús

Congreso; IV Congreso Latinoamericano de Química Bioinorgánica (IVLABIC); 2014

Química Bioinorgánica (IVLABIC)

Microporous Coordination Polymers (MCPs also known as Metal Organic Frameworks or MOFs) are a relatively new class of organic-inorganic hybrid crystalline solids constituted by metal ion clusters and organic linkers forming a porous network. Because of the great variety of possible metal ions and linkers, MCPs are a highly tunable material in terms of its pore dimension and shape, with a great number of possible surface functional groups present. This leads in turn, to a wide range of possible applications such as gas and liquid phase adsorptive separations and purifications, membrane based separations1-3, catalysis4, drug delivery5, and energy-relevant gas storage6. β-carbolines (βCs) are a family of alkaloids widely found in nature highly active from a biological point of view. They have shown activity against several microorganisms (bacteria, parasites, viruses, etc.). Upon excitation, the antimicrobial activity of these molecules is considerably increased. The photosensitizing properties of βCs and some related derivatives have been recently well studied and documented. On cell-free DNA, photoexcited harmine (Scheme 1a) induces single strand-breaks (SSB), 8-oxo-7,8-dihydroguanine and pyrimidine dimers formation (CPDs)7-10.