DNA damage induced by bare and loaded Microporous Coordination Polymers from their ground and electronic excited states

JUAN G. YAÑUK &; MARIA. L ALOMAR &; M. MICAELA GONZÁLEZ; FRANCISCO SIMON; ROSA ERRA-BALSELLS; MATIAS RAFTI; FRANCO M CABRERIZO; THESE AUTHORS CONTRIBUTED EQUALLY=&

PHYSICAL CHEMISTRY CHEMICAL PHYSICS

ROYAL SOC CHEMISTRY

Lugar: CAMBRIDGE; Año: 2015

1463-9076

NOTA: & Yañuk and Alomar: These authors contributed equally. Mensaje reenviado de pccp@rsc.org Fecha: Mon, 13 Apr 2015 11:20:06 -0400 (EDT) De: pccp@rsc.org Asunto: Physical Chemistry Chemical Physics - Decision on Manuscript ID CP-COM-01-2015-000308.R2 Para: fcabrerizo@intech.gov.ar 13-Apr-2015 Dear Dr Cabrerizo MANUSCRIPT ID: CP-COM-01-2015-000308.R2 TITLE: DNA damage induced by bare and loaded Microporous Coordination Polymers from their ground and electronic excited states Thank you for submitting your revised manuscript. I am satisfied with the changes you have made, and I am therefore pleased to inform you that your paper has been accepted for publication in Physical Chemistry Chemical Physics. Proofs for correction will be sent to you by e-mail in due course. If you have requested publication of the Accepted Manuscript, please note that this is in progress and the article should shortly be available online. Please note that authors are responsible for the final proof-reading of manuscripts. It is imperative that you check your proofs (including any tabulated data and figures) very carefully. Proof corrections will need to be returned within 48 hours of receipt where possible. All corrections should be sent at the same time. Papers are published as Advance Articles on the web as soon as possible after we receive proof corrections from the authors. Late corrections cannot be incorporated after publication of the Advanced Article. The RSC supplies PDF reprints of papers to authors for free. If you would like to purchase printed reprints of your paper, please visit http://www.rsc.org/Publishing/Journals/guidelines/PaperReprints/index.asp for full details. RSC Publishing is pleased to offer increased choice to journal authors - accepted articles can be made openly available to all on the web, for a fee. For further details visit http://www.rsc.org/publishing/journals/openscience/ Finally, please note that all RSC journal authors are entitled to a 25% discount on RSC books ? please visit http://www.rsc.org/Shop/discounts.asp for further details. Thank you for your contribution to Physical Chemistry Chemical Physics. I look forward to receiving your next submission. Yours sincerely Dannielle Whittaker Publishing Editor Royal Society of Chemistry, Thomas Graham House Science Park, Milton Road, Cambridge CB4 0WF Email: whittakerd@rsc.org Abstract. We report on interactions of cell free double- stranded DNA (dsDNA) with a selected subgroup of Microporous Coordination Polymers (MCPs). In particular, we have studied the influence of different metal ion constituents and chemically modified linkers using a set of five benzene carboxylate-based MCPs. Our results suggest that DNA moiety can be structurally modified via two different ways: by direct MCPs-dsDNA interaction and/or through photosensitized processes. The extent of the observed damage was found to be strongly dependent on the charge density of the material. The potential use of the MCPs tested as inert carriers of photosensitizers was demonstrated by analyzing the interaction between dsDNA and harmine-loaded Cr-based materials, both in the absence of light and upon UVA irradiation.