Subclinic effect of the administration of T-2 Toxin and Nivalenol in mice

PACIN, ANA; REALE, CARLOS; MIRENGUI, HEBE; ORELLANA, LILIANA; BOENTE, GRACIELA

Mycotoxin Research

Society for Mycotoxin Research (Gesellschaft für Mykotoxinforschung)

Lugar: Mainz; Año: 1994 vol. 10 p. 85 - 96

Four experiments using T-2 toxin and nivalenol at different dosage, which represented the 25% and 40% of the LD50 (experiment A: 1.04mg of T2 toxin per kilogram of body weight, experiment B: 2.34 mg of T2toxin/kg bw, experiment C: 1.04mg of  T2toxin/kg bw and  2.34 mg of T2toxin/kg bw, experiment D: 0.82 mg of toxin/kg bw, and 1.845 mg of nivalenol/kgbw) were conducted on 400 mice. Both toxins were administered to mice at different ages (experiments A and B were adults, experiments C and D were young) by intraperitoneal single injection, and the clinical signs, hematological variables and histoanatomo pathological changes were studied. Al animals survived. No changes anatomo histopathological nor significative differences in weight were observed. Different behaviors were found for nivalenol and T2 toxin. The most significan change was the increase in the level of monocytes in old animals, so this could be a biological indicator for T2 toxin subclinical intoxication.