INVESTIGADORES
GIRARDINI BROVELLI Javier Enrique
artículos
Título:
Synthesis of triazole derivatives of levoglucosenone as promising anticancer agents. Effective exploration of the chemical space through retro-aza-Michael//aza-Michael isomerizations
Autor/es:
TSAI, YI-HSUAN; BORINI ETICHETTI, CARLA M.; DI BENEDETTO, CAROLINA; GIRARDINI, JAVIER E.; MARTINS, FELIPE TERRA; SPANEVELLO, ROLANDO ANGEL; SUÁREZ, ALEJANDRA GRACIELA; SAROTTI, ARIEL M.
Revista:
JOURNAL OF ORGANIC CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2018
ISSN:
0022-3263
Resumen:
The design and synthesis of biomass-derived triazoles and the in vitro evaluation as potential anticancer agents is described. The discovery of base-catalyzed retro-aza-Michael//aza-Michael isomerizations allowed the exploration of the chemical space by affording novel types of triazoles, difficult to obtain otherwise. Following this strategy, 2,4-disubstituted-1,2,3-triazoles could be efficiently obtained from the corresponding 1,4-disubstituted analogues.