INVESTIGADORES
DEWEY Ricardo Alfredo
artículos
Título:
Disease-Modifying Immunotherapy for the Management of Autoimmune Diabetes.
Autor/es:
C.N.CASTRO; A.E. BARCALA TABARROZI; M.A. NOGUEROL; A.C. LIBERMAN; R.A. DEWEY; E. ARZT; A.E. MORELLI; M.J. PERONE
Revista:
NEUROIMMUNOMODULATION.
Editorial:
S. Karger AG
Referencias:
Lugar: Basel ; Año: 2010 vol. 17 p. 173 - 176
ISSN:
1021-7401
Resumen:
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that destroys the insulin-secreting beta-cells of the pancreas. It is now possible to predict those candidates that will progress to T1D before the full onset of the disease. Prevention of uncontrollable autoimmunity against beta-cells in therapies for T1D is mandatory to preserve the beta-cell mass. Therefore, immunomodulatory strategies directed to inhibiting the activity of self-reactive T cell clones as well as induction of regulatory T cells would be beneficial for prevention of T1D or recurrence of beta-cell autoimmunity against islet cell allografts.