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Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors

Med; Año: 2023 vol. 4 p. 113 - 129

NUÑEZ, NICOLÁS GONZALO; SCHMID, JONAS; POWER, LAURA; ALBERTI, CHIARA; KRISHNARAJAH, SINDUYA; KREUTMAIR, STEFANIE; UNGER, SUSANNE; BLANCO, SEBASTIÁN; KONIGHEIM, BRENDA; MARÍN, CONSTANZA; ONOFRIO, LUISINA; KIENZLER, JENNY CHRISTINE; COSTA-PEREIRA, SARA; INGELFINGER, FLORIAN; CERBÁN, FABIO; CHIAPELLO, LAURA; MONTES, CAROLINA; MOTRÁN, CRISTINA; DUTTO, JEREMÍAS; ALMADA, LAURA; BOFFELLI, LUCÍA; SPINSANTI, LORENA; DÍAZ, ADRIÁN; RIVAROLA, MARÍA ELISA; BIOQ, JAVIER AGUILAR; BERANEK, MAURICIO; PASINOVICH, MARINA E.; CASTELLI, JUAN M.; VIZZOTTI, CARLA; SCHAEFER, MAXIMILIAN; VILLAR-VESGA, JUAN; MUNDT, SARAH; MERTEN, CARLA HELENA; SETHI, AAKRITI; WERTHEIMER, TOBIAS; LUTZ, MIRJAM; VANOAICA, DANUSIA; SOTOMAYOR, CLAUDIA; GRUPPI, ADRIANA; MÜNZ, CHRISTIAN; CARDOZO, DIEGO; BARBÁS, GABRIELA; LOPEZ, LAURA; CARREÑO, PAULA; CASTRO, GONZALO; RABOY, ELIAS; GALLEGO, SANDRA; MORÓN, GABRIEL; CERVI, LAURA; ACOSTA RODRIGUEZ, EVA V.; MALETTO, BELKYS A.; MACCIONI, MARIANA; BECHER, BURKHARD

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

NATURE IMMUNOLOGY (PRINT); Año: 2023

DIEBOLD, MARTIN; GALLI, EDOARDO; KOPF, ANDREAS; SANDERSON, NICHOLAS; CALLEGARI, ILARIA; INGELFINGER, FLORIAN; NÚÑEZ, NICOLÁS GONZALO; BENKERT, PASCAL; KAPPOS, LUDWIG; KUHLE, JENS; BECHER, BURKHARD; CLAASSEN, MANFRED; DERFUSS, TOBIAS

Immunological Predictors of Dimethyl Fumarate-Induced Lymphopenia

ANNALS OF NEUROLOGY; Año: 2022 vol. 91 p. 676 - 681

HO, JENNY N.H.G.; SCHMIDT, DOMINIK; LOWINUS, THERESA; RYOO, JEONGMIN; DOPFER, ELAINE-PASHUPATI; GONZALO NÚÑEZ, NICOLÁS; COSTA-PEREIRA, SARA; TOFFALORI, CRISTINA; PUNTA, MARCO; FETSCH, VIKTOR; WERTHEIMER, TOBIAS; RITTMANN, MARIE-CLAIRE; BRAUN, LUKAS M.; FOLLO, MARIE; BRIERE, CHRISTELLE; VINNAKOTA, JANAKI MANOJA; LANGENBACH, MARLENE; KOPPERS, FELICITAS; SHOUMARIYEH, KHALID; ENGEL, HELENA; RÜCKERT, TAMINA; MÄRKLIN, MELANIE; HOLZMAYER, SAMUEL; ILLERT, ANNA L.; MAGON, FEDERICA; ANDRIEUX, GEOFFROY; DUQUESNE, SANDRA; PFEIFER, DIETMAR; STANIEK, JULIAN; RIZZI, MARTA; MIETHING, CORNELIUS; KÖHLER, NATALIE; DUYSTER, JUSTUS; MENSSEN, HANS D.; BOERRIES, MELANIE; BUESCHER, JOERG M.; CABEZAS-WALLSCHEID, NINA; BLAZAR, BRUCE R.; APOSTOLOVA, PETYA; VAGO, LUCA; PEARCE, ERIKA L.; BECHER, BURKHARD; ZEISER, ROBERT

Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation

BLOOD, THE JOURNAL OF THE AMERICAN SOCIETY OF HEMATOLOGY - PRINT; Año: 2022 vol. 140 p. 1167 - 1181

VINCENTI, ILENA; PAGE, NICOLAS; STEINBACH, KARIN; YERMANOS, ALEXANDER; LEMEILLE, SYLVAIN; NUNEZ, NICOLAS; KREUTZFELDT, MARIO; KLIMEK, BOGNA; DI LIBERTO, GIOVANNI; EGERVARI, KRISTOF; PICCINNO, MARGOT; SHAMMAS, GHAZAL; MARIOTTE, ALEXANDRE; FONTA, NICOLAS; LIAUDET, NICOLAS; SHLESINGER, DANIELLE; LIUZZI, ANNA RITA; WAGNER, INGRID; SAADI, CYNTHIA; STADELMANN, CHRISTINE; REDDY, SAI; BECHER, BURKHARD; MERKLER, DORON

Tissue-resident memory CD8+ T cells cooperate with CD4+ T cells to drive compartmentalized immunopathology in the CNS

Science Translational Medicine; Año: 2022 vol. 14

NALIO RAMOS, RODRIGO; MISSOLO-KOUSSOU, YOANN; GERBER-FERDER, YOHAN; BROMLEY, CHRISTIAN P.; BUGATTI, MATTIA; NÚÑEZ, NICOLAS GONZALO; TOSELLO BOARI, JIMENA; RICHER, WILFRID; MENGER, LAURIE; DENIZEAU, JORDAN; SEDLIK, CHRISTINE; CAUDANA, PAMELA; KOTSIAS, FIORELLA; NIBORSKI, LETICIA L.; VIEL, SOPHIE; BOHEC, MYLÈNE; LAMEIRAS, SONIA; BAULANDE, SYLVAIN; LESAGE, LAËTITIA; NICOLAS, ANDRÉ; MESEURE, DIDIER; VINCENT-SALOMON, ANNE; REYAL, FABIEN; DUTERTRE, CHARLES-ANTOINE; GINHOUX, FLORENT; VIMEUX, LENE; DONNADIEU, EMMANUEL; BUTTARD, BÉNÉDICTE; GALON, JÉRÔME; ZELENAY, SANTIAGO; VERMI, WILLIAM; GUERMONPREZ, PIERRE; PIAGGIO, ELIANE; HELFT, JULIE

Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

CELL; Año: 2022 vol. 185 p. 1189 - 1207

FALLEGGER, ANGELA; PRIOLA, MARTINA; ARTOLA-BORÁN, MARIELA; NÚÑEZ, NICOLÁS GONZALO; WILD, SEBASTIAN; GURTNER, ALESSANDRA; BECHER, BURKHARD; YOUSEFI, SHIDA; SIMON, HANS-UWE; ARNOLD, ISABELLE C.; MÜLLER, ANNE

TGF-β production by eosinophils drives the expansion of peripherally induced neuropilin− RORγt+ regulatory T-cells during bacterial and allergen challenge

MUCOSAL IMMUNOLOGY; Año: 2022 vol. 15 p. 504 - 514

KREUTMAIR, STEFANIE; KAUFFMANN, MANUEL; UNGER, SUSANNE; INGELFINGER, FLORIAN; NÚÑEZ, NICOLÁS GONZALO; ALBERTI, CHIARA; DE FEO, DONATELLA; KRISHNARAJAH, SINDUYA; FRIEBEL, EKATERINA; ULUTEKIN, CAN; BABAEI, SEPIDEH; GABORIT, BENJAMIN; LUTZ, MIRJAM; JURADO, NICOLE PUERTAS; MALEK, NISAR P.; GÖPEL, SIRI; ROSENBERGER, PETER; HÄBERLE, HELENE A.; AYOUB, IKRAM; AL-HAJJ, SALLY; CLAASSEN, MANFRED; LIBLAU, ROLAND; MARTIN-BLONDEL, GUILLAUME; BITZER, MICHAEL; ROQUILLY, ANTOINE; BECHER, BURKHARD

Preexisting comorbidities shape the immune response associated with severe COVID-19

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY; Año: 2022 vol. 150 p. 312 - 324

DIEBOLD, MARTIN; GALLI, EDOARDO; KOPF, ANDREAS; SANDERSON, NICHOLAS S.R.; CALLEGARI, ILARIA; BENKERT, PASCAL; NUÑEZ, NICOLAS GONZALO; INGELFINGER, FLORIAN; HERMS, STEFAN; CICHON, SVEN; KAPPOS, LUDWIG; KUHLE, JENS; BECHER, BURKHARD; CLAASSEN, MANFRED; DERFUSS, TOBIAS

High-dimensional immune profiling identifies a biomarker to monitor dimethyl fumarate response in multiple sclerosis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2022 vol. 119

GURTNER, ALESSANDRA; BORRELLI, COSTANZA; GONZALEZ-PEREZ, IGNACIO; BACH, KARSTEN; ACAR, ILHAN E.; NÚÑEZ, NICOLÁS G.; CREPAZ, DANIEL; HANDLER, KRISTINA; VU, VIVIAN P.; LAFZI, ATEFEH; STIRM, KRISTIN; RAJU, DEEKSHA; GSCHWEND, JULIA; BASLER, KONRAD; SCHNEIDER, CHRISTOPH; SLACK, EMMA; VALENTA, TOMAS; BECHER, BURKHARD; KREBS, PHILIPPE; MOOR, ANDREAS E.; ARNOLD, ISABELLE C.

Active eosinophils regulate host defence and immune responses in colitis

NATURE; Año: 2022

GATTI, GERARDO; BETTS, COURTNEY; ROCHA, DARÍO; NICOLA, MARIBEL; GRUPE, VERÓNICA; DITADA, CECILIA; NUÑEZ, NICOLAS G.; ROSELLI, EMILIANO; ARAYA, PAULA; DUTTO, JEREMÍAS; BOFFELLI, LUCIA; FERNÁNDEZ, ELMER; COUSSENS, LISA M.; MACCIONI, MARIANA

High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer

BREAST CANCER RESEARCH; Año: 2021 vol. 23

TALLÓN DE LARA, PAULINO; CASTAÑÓN, HÉCTOR; VERMEER, MARIJNE; NÚÑEZ, NICOLÁS; SILINA, KARINA; SOBOTTKA, BETTINA; URDINEZ, JOAQUÍN; CECCONI, VIRGINIA; YAGITA, HIDEO; MOVAHEDIAN ATTAR, FARKHONDEH; HILTBRUNNER, STEFANIE; GLARNER, ISABELLE; MOCH, HOLGER; TUGUES, SÒNIA; BECHER, BURKHARD; VAN DEN BROEK, MARIES

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

NATURE COMMUNICATIONS; Año: 2021 vol. 12

KREUTMAIR, STEFANIE; UNGER, SUSANNE; NÚÑEZ, NICOLÁS GONZALO; INGELFINGER, FLORIAN; ALBERTI, CHIARA; DE FEO, DONATELLA; KRISHNARAJAH, SINDUYA; KAUFFMANN, MANUEL; FRIEBEL, EKATERINA; BABAEI, SEPIDEH; GABORIT, BENJAMIN; LUTZ, MIRJAM; JURADO, NICOLE PUERTAS; MALEK, NISAR P.; GOEPEL, SIRI; ROSENBERGER, PETER; HÄBERLE, HELENE A.; AYOUB, IKRAM; AL-HAJJ, SALLY; NILSSON, JAKOB; CLAASSEN, MANFRED; LIBLAU, ROLAND; MARTIN-BLONDEL, GUILLAUME; BITZER, MICHAEL; ROQUILLY, ANTOINE; BECHER, BURKHARD

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia

IMMUNITY; Año: 2021

AGLIARDI, GIULIA; LIUZZI, ANNA RITA; HOTBLACK, ALASTAIR; DE FEO, DONATELLA; NÚÑEZ, NICOLÁS; STOWE, CASSANDRA L.; FRIEBEL, EKATERINA; NANNINI, FRANCESCO; RINDLISBACHER, LUKAS; ROBERTS, THOMAS A.; RAMASAWMY, RAJIV; WILLIAMS, IWAN P.; SIOW, BERNARD M.; LYTHGOE, MARK F.; KALBER, TAMMY L.; QUEZADA, SERGIO A.; PULE, MARTIN A.; TUGUES, SONIA; STRAATHOF, KARIN; BECHER, BURKHARD

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

NATURE COMMUNICATIONS; Año: 2021 vol. 12

PFISTER, DOMINIK; NÚÑEZ, NICOLÁS GONZALO; PINYOL, ROSER; GOVAERE, OLIVIER; PINTER, MATTHIAS; SZYDLOWSKA, MARTA; GUPTA, REVANT; QIU, MENGJIE; DECZKOWSKA, ALEKSANDRA; WEINER, ASSAF; MÜLLER, FLORIAN; SINHA, ANKIT; FRIEBEL, EKATERINA; ENGLEITNER, THOMAS; LENGGENHAGER, DANIELA; MONCSEK, ANJA; HEIDE, DANIJELA; STIRM, KRISTIN; KOSLA, JAN; KOTSILITI, ELENI; LEONE, VALENTINA; DUDEK, MICHAEL; YOUSUF, SUHAIL; INVERSO, DONATO; SINGH, INDRABAHADUR; TEIJEIRO, ANA; CASTET, FLORIAN; MONTIRONI, CARLA; HABER, PHILIPP K.; TINIAKOS, DINA; BEDOSSA, PIERRE; COCKELL, SIMON; YOUNES, RAMY; VACCA, MICHELE; MARRA, FABIO; SCHATTENBERG, JÖRN M.; ALLISON, MICHAEL; BUGIANESI, ELISABETTA; RATZIU, VLAD; PRESSIANI, TIZIANA; DALESSIO, ANTONIO; PERSONENI, NICOLA; RIMASSA, LORENZA; DALY, ANN K.; SCHEINER, BERNHARD; POMEJ, KATHARINA; KIRSTEIN, MARTHA M.; VOGEL, ARNDT; PECK-RADOSAVLJEVIC, MARKUS; HUCKE, FLORIAN; FINKELMEIER, FABIAN; WAIDMANN, OLIVER; TROJAN, JÖRG; SCHULZE, KORNELIUS; WEGE, HENNING; KOCH, SANDRA; WEINMANN, ARNDT; BUETER, MARCO; RÖS

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

NATURE; Año: 2021 vol. 592 p. 450 - 456

REGEN, TOMMY; ISAAC, SANDRINE; AMORIM, ANA; NÚÑEZ, NICOLÁS GONZALO; HAUPTMANN, JUDITH; SHANMUGAVADIVU, ARTHI; KLEIN, MATTHIAS; SANKOWSKI, ROMAN; MUFAZALOV, ILGIZ A.; YOGEV, NIR; HUPPERT, JULA; WANKE, FLORIAN; WITTING, MICHAEL; GRILL, ALEXANDRA; GÁLVEZ, ERIC J.C.; NIKOLAEV, ALEXEI; BLANFELD, MICHAELA; PRINZ, IMMO; SCHMITT-KOPPLIN, PHILIPPE; STROWIG, TILL; REINHARDT, CHRISTOPH; PRINZ, MARCO; BOPP, TOBIAS; BECHER, BURKHARD; UBEDA, CARLES; WAISMAN, ARI

IL-17 controls central nervous system autoimmunity through the intestinal microbiome

Science Immunology; Año: 2021 vol. 6

LIGEON, LAURE-ANNE; PENA-FRANCESCH, MARIA; VANOAICA, LILIANA DANUSIA; NÚÑEZ, NICOLÁS GONZALO; TALWAR, DEEPTI; DICK, TOBIAS P.; MÜNZ, CHRISTIAN

Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation

NATURE COMMUNICATIONS; Año: 2021 vol. 12

DUCIMETIÈRE, LAURA; LUCCHIARI, GIULIA; LITSCHER, GIOANA; NATER, MARC; HEEB, LAURA; NUÑEZ, NICOLÁS GONZALO; WYSS, LAURA; BURRI, DOMINIK; VERMEER, MARIJNE; GSCHWEND, JULIA; MOOR, ANDREAS E.; BECHER, BURKHARD; VAN DEN BROEK, MARIES; TUGUES, SONIA

Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2021 vol. 118

INGELFINGER, FLORIAN; KRISHNARAJAH, SINDUYA; KRAMER, MICHAEL; UTZ, SEBASTIAN G.; GALLI, EDOARDO; LUTZ, MIRJAM; ZWICKY, PASCALE; AKARCA, AYSE U.; JURADO, NICOLE PUERTAS; ULUTEKIN, CAN; BAMERT, DAVID; WIDMER, CORINNE C.; PICCOLI, LUCA; SALLUSTO, FEDERICA; NÚÑEZ, NICOLÁS G.; MARAFIOTI, TERESA; SCHNEITER, DIDIER; OPITZ, ISABELLE; LANZAVECCHIA, ANTONIO; JUNG, HANS H.; DE FEO, DONATELLA; MUNDT, SARAH; SCHREINER, BETTINA; BECHER, BURKHARD

Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature

ACTA NEUROPATHOLOGICA; Año: 2021 vol. 141 p. 901 - 915

RAMELLO, MARIA C.; NÚÑEZ, NICOLÁS G.; TOSELLO BOARI, JIMENA; BOSSIO, SABRINA N.; CANALE, FERNANDO P.; ABRATE, CAROLINA; PONCE, NICOLAS; DEL CASTILLO, ANDRÉS; LEDESMA, MARTA; VIEL, SOPHIE; RICHER, WILFRID; SEDLIK, CHRISTINE; TIRABOSCHI, CAROLINA; MUÑOZ, MARCOS; COMPAGNO, DANIEL; GRUPPI, ADRIANA; ACOSTA RODRÍGUEZ, EVA V.; PIAGGIO, ELIANE; MONTES, CAROLINA L.

Polyfunctional KLRG-1+CD57+ Senescent CD4+ T Cells Infiltrate Tumors and Are Expanded in Peripheral Blood From Breast Cancer Patients

Frontiers in Immunology; Año: 2021 vol. 12

STIRM, KRISTIN; LEARY, PETER; BERTRAM, KATRIN; NÚÑEZ, NICOLÁS GONZALO; WÜST, DARIA; BOUDESCO, CHRISTOPHE; VERHOEYEN, ELS; ZENZ, THORSTEN; BECHER, BURKHARD; MENTER, THOMAS; TZANKOV, ALEXANDAR; MÜLLER, ANNE

Tumor cell-derived IL-10 promotes cell-autonomous growth and immune escape in diffuse large B-cell lymphoma

OncoImmunology; Año: 2021 vol. 10

MYBURGH, RENIER; KIEFER, JONATHAN D.; RUSSKAMP, NORMAN F.; MAGNANI, CHIARA F.; NUÑEZ, NICOLÁS; SIMONIS, ALEXANDER; PFISTER, SUREMA; WILK, C. MATTHIAS; MCHUGH, DONAL; FRIEMEL, JULIANE; MÜLLER, ANTONIA M.; BECHER, BURKHARD; MÜNZ, CHRISTIAN; VAN DEN BROEK, MARIES; NERI, DARIO; MANZ, MARKUS G.

Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells

LEUKEMIA; Año: 2020 vol. 34 p. 2688 - 2703

ASLAN, KATRIN; TURCO, VERENA; BLOBNER, JENS; SONNER, JANA K.; LIUZZI, ANNA RITA; NÚÑEZ, NICOLÁS GONZALO; DE FEO, DONATELLA; KICKINGEREDER, PHILIPP; FISCHER, MANUEL; GREEN, ED; SADIK, AHMED; FRIEDRICH, MIRCO; SANGHVI, KHWAB; KILIAN, MICHAEL; CICHON, FREDERIK; WOLF, LARA; JÄHNE, KRISTINE; VON LANDENBERG, ANNA; BUNSE, LUKAS; SAHM, FELIX; SCHRIMPF, DANIEL; MEYER, JOCHEN; ALEXANDER, ALLEN; BRUGNARA, GIANLUCA; RÖTH, RALPH; PFLEIDERER, KIRA; NIESLER, BEATE; VON DEIMLING, ANDREAS; OPITZ, CHRISTIANE; BRECKWOLDT, MICHAEL O.; HEILAND, SABINE; BENDSZUS, MARTIN; WICK, WOLFGANG; BECHER, BURKHARD; PLATTEN, MICHAEL

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

NATURE COMMUNICATIONS; Año: 2020 vol. 11

GEORGANAKI, MARIA; RAMACHANDRAN, MOHANRAJ; TUIT, SANDER; NÚÑEZ, NICOLÁS GONZALO; KARAMPATZAKIS, ALEXANDROS; FOTAKI, GRAMMATIKI; VAN HOOREN, LUUK; HUANG, HUA; LUGANO, ROBERTA; ULAS, THOMAS; KAUNISTO, AURA; HOLLAND, ERIC C; ELLMARK, PETER; MANGSBO, SARA M; SCHULTZE, JOACHIM; ESSAND, MAGNUS; TUGUES, SONIA; DIMBERG, ANNA

Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

OncoImmunology; Año: 2020 vol. 9

NÚÑEZ, NICOLAS GONZALO; TOSELLO BOARI, JIMENA; RAMOS, RODRIGO NALIO; RICHER, WILFRID; CAGNARD, NICOLAS; ANDERFUHREN, CYRILL DIMITRI; NIBORSKI, LETICIA LAURA; BIGOT, JEREMY; MESEURE, DIDIER; DE LA ROCHERE, PHILIPPE; MILDER, MAUD; VIEL, SOPHIE; LOIRAT, DELPHINE; PÉROL, LOUIS; VINCENT-SALOMON, ANNE; SASTRE-GARAU, XAVIER; BURKHARD, BECHER; SEDLIK, CHRISTINE; LANTZ, OLIVIER; AMIGORENA, SEBASTIAN; PIAGGIO, ELIANE

Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

NATURE COMMUNICATIONS; Año: 2020 vol. 11

FRIEBEL, EKATERINA; KAPOLOU, KONSTANTINA; UNGER, SUSANNE; NÚÑEZ, NICOLÁS GONZALO; UTZ, SEBASTIAN; RUSHING, ELISABETH JANE; REGLI, LUCA; WELLER, MICHAEL; GRETER, MELANIE; TUGUES, SONIA; NEIDERT, MARIAN CHRISTOPH; BECHER, BURKHARD

Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes

CELL; Año: 2020 vol. 181 p. 1626 - 1642

BOURDELY, PIERRE; ANSELMI, GIORGIO; VAIVODE, KRISTINE; RAMOS, RODRIGO NALIO; MISSOLO-KOUSSOU, YOANN; HIDALGO, SOFIA; TOSSELO, JIMENA; NUÑEZ, NICOLAS; RICHER, WILFRID; VINCENT-SALOMON, ANNE; SAXENA, ALKA; WOOD, KRISTIE; LLADSER, ALVARO; PIAGGIO, ELIANE; HELFT, JULIE; GUERMONPREZ, PIERRE

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

IMMUNITY; Año: 2020 vol. 53 p. 335 - 352

GALLI, EDOARDO; FRIEBEL, EKATERINA; INGELFINGER, FLORIAN; UNGER, SUSANNE; NÚÑEZ, NICOLÁS GONZALO; BECHER, BURKHARD

The end of omics? High dimensional single cell analysis in precision medicine

EUROPEAN JOURNAL OF IMMUNOLOGY; Año: 2019

CAUDANA, PAMELA; NÚÑEZ, NICOLAS; DELAROCHERE, PHILIPPE; PINTO, ANAÏS; DENIZEAU, JORDAN; ALONSO, RUBY; NIBORSKI, LETICIA; LANTZ, OLIVIER; SEDLIK, CHRISTINE; PIAGGIO, ELIANE

IL2/anti-IL2 complex combined with CTLA-4, but not PD-1, blockade rescues antitumor NK cell function by regulatory T-cell modulation

Cancer Immunology Research; Año: 2019

HUTMACHER, CORNELIA; NÚÑEZ, NICOLAS; LIUZZI, ANNA RITA; BECHER, BURKHARD; NERI, DARIO

Targeted delivery of IL2 to the tumor stroma potentiates the action of immune checkpoint inhibitors by preferential activation of NK and CD8+ T cells

Cancer Immunology Research; Año: 2019

ROSELLI, EMILIANO; ARAYA, PAULA; NÚÑEZ, NICOLÁS GONZALO; GATTI, GERARDO; GRAZIANO, FRANCESCA; SEDLIK, CHRISTINE; BENAROCH, PHILIPPE; PIAGGIO, ELIANE; MACCIONI, MARIANA

TLR3 Activation of Intratumoral CD103+ Dendritic Cells Modifies the Tumor Infiltrate Conferring Anti-tumor Immunity

Frontiers in Immunology; Año: 2019 vol. 10

CHATTERJEE, BITHI; DENG, YUN; HOLLER, ANGELIKA; NUNEZ, NICOLAS; AZZI, TARIK; VANOAICA, LILIANA DANUSIA; MÜLLER, ANNE; ZDIMEROVA, HANA; ANTSIFEROVA, OLGA; ZBINDEN, ANDREA; CAPAUL, RICCARDA; DREYER, JOHANNES H.; NADAL, DAVID; BECHER, BURKHARD; ROBINSON, MARK D.; STAUSS, HANS; MÜNZ, CHRISTIAN

CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo

PLOS Pathogens; Año: 2019 vol. 15

BRUMMELMAN, JOLANDA; HAFTMANN, CLAUDIA; NÚÑEZ, NICOLÁS GONZALO; ALVISI, GIORGIA; MAZZA, EMILIA M. C.; BECHER, BURKHARD; LUGLI, ENRICO

Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry

NATURE PROTOCOLS; Año: 2019

MERLOTTI, ANTONELA; MALIZIA, ALVARO LÓPEZ; MICHEA, PAULA; BONTE, PIERRE-EMMANUEL; GOUDOT, CHRISTEL; CARREGAL, MARÍA SOL; NUÑEZ, NICOLÁS; SEDLIK, CHRISTINE; CEBALLOS, ANA; SOUMELIS, VASSILI; AMIGORENA, SEBASTIÁN; GEFFNER, JORGE; PIAGGIO, ELIANE; SABATTE, JUAN

Aberrant fucosylation enables breast cancer clusterin to interact with dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN)

OncoImmunology; Año: 2019 vol. 8

HÜLSDÜNKER, JAN; THOMAS, OLIVER S.; HARING, EILEEN; UNGER, SUSANNE; NÚÑEZ, NICOLÁS GONZALO; TUGUES, SONIA; GAO, ZHAN; DUQUESNE, SANDRA; CYWES-BENTLEY, COLETTE; OYARDI, OZLEM; KIRSCHNEK, SUSANNE; SCHMITT-GRAEFF, ANNETTE; PABST, OLIVER; KOENECKE, CHRISTIAN; DUYSTER, JUSTUS; APOSTOLOVA, PETYA; BLASER, MARTIN J.; BECHER, BURKHARD; PIER, GERALD B.; HÄCKER, GEORG; ZEISER, ROBERT

Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2019 vol. 116 p. 20700 - 20706

ARAYA, PAULA; WAUGH, KATHERINE A.; SULLIVAN, KELLY D.; NÚÑEZ, NICOLÁS G.; ROSELLI, EMILIANO; SMITH, KEITH P.; GRANRATH, ROSS E.; RACHUBINSKI, ANGELA L.; ESTRADA, BELINDA ENRIQUEZ; BUTCHER, ERIC T.; MINTER, ROSS; TUTTLE, KATHRYN D.; BRUNO, TULLIA C.; MACCIONI, MARIANA; ESPINOSA, JOAQUÍN M.

Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; Año: 2019 vol. 116 p. 24231 - 24241

LÍNDEZ, ADRIÀ-ARNAU MARTÍ; DUNAND-SAUTHIER, ISABELLE; CONTI, MARK; GOBET, FLORIAN; NÚÑEZ, NICOLÁS; HANNICH, J. THOMAS; RIEZMAN, HOWARD; GEIGER, ROGER; PIERSIGILLI, ALESSANDRA; HAHN, KERSTIN; LEMEILLE, SYLVAIN; BECHER, BURKHARD; DE SMEDT, THIBAUT; HUGUES, STÉPHANIE; REITH, WALTER

Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy

JCI Insight; Año: 2019 vol. 4

CANALE, FERNANDO P.; RAMELLO, MARÍA C.; NÚÑEZ, NICOLÁS; FURLAN, CINTIA L. ARAUJO; BOSSIO, SABRINA N.; SERRÁN, MELISA GOROSITO; BOARI, JIMENA TOSELLO; DEL CASTILLO, ANDRÉS; LEDESMA, MARTA; SEDLIK, CHRISTINE; PIAGGIO, ELIANE; GRUPPI, ADRIANA; RODRÍGUEZ, EVA V. ACOSTA; MONTES, CAROLINA L.

CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8 + T Cells

CANCER RESEARCH; Año: 2018 vol. 78 p. 115 - 128

ALONSO, RUBY; FLAMENT, HÉLOÏSE; LEMOINE, SÉBASTIEN; SEDLIK, CHRISTINE; BOTTASSO, EMANUEL; PÉGUILLET, ISABEL; PRÉMEL, VIRGINIE; DENIZEAU, JORDAN; SALOU, MARION; DARBOIS, AURÉLIE; NÚÑEZ, NICOLÁS GONZALO; SALOMON, BENOIT; GROSS, DAVID; PIAGGIO, ELIANE; LANTZ, OLIVIER

Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node

NATURE COMMUNICATIONS; Año: 2018 vol. 9

CANALE, FERNANDO P.; RAMELLO, MARÍA C.; NÚÑEZ, NICOLÁS; BOSSIO, SABRINA N.; PIAGGIO, ELIANE; GRUPPI, ADRIANA; RODRÍGUEZ, EVA V. ACOSTA; MONTES, CAROLINA L.

CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8 + T Cells—Response

CANCER RESEARCH; Año: 2018

TOSELLO BOARI, JIMENA; ARAUJO FURLAN, CINTIA L.; FIOCCA VERNENGO, FACUNDO; RODRIGUEZ, CONSTANZA; RAMELLO, MARÍA C.; AMEZCUA VESELY, MARÍA C.; GOROSITO SERRÁN, MELISA; NUÑEZ, NICOLÁS G.; RICHER, WILFRID; PIAGGIO, ELIANE; MONTES, CAROLINA L.; GRUPPI, ADRIANA; ACOSTA RODRÍGUEZ, EVA V.

IL-17RA-Signaling Modulates CD8+ T Cell Survival and Exhaustion During Trypanosoma cruzi Infection

Frontiers in Immunology; Año: 2018 vol. 9

TUGUES, SONIA; AMORIM, ANA; SPATH, SABINE; MARTIN-BLONDEL, GUILLAUME; SCHREINER, BETTINA; DE FEO, DONATELLA; LUTZ, MIRJAM; GUSCETTI, FRANCO; APOSTOLOVA, PETYA; HAFTMANN, CLAUDIA; HASSELBLATT, PETER; NÚÑEZ, NICOLAS G.; HOTTIGER, MICHAEL O.; VAN DEN BROEK, MARIES; MANZ, MARKUS G.; ZEISER, ROBERT; BECHER, BURKHARD

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF–licensed myeloid cells

Science Translational Medicine; Año: 2018 vol. 10

FRAZAO, ALEXANDRA; MESSAOUDENE, MERIEM; NÚÑEZ, NICOLAS; DULPHY, NICOLAS; ROUSSIN, FRANCE; SEDLIK, CHRISTINE; ZITVOGEL, LAURENCE; PIAGGIO, ELIANE; TOUBERT, ANTOINE; CAIGNARD, ANNE

CD16+NKG2Ahigh Natural Killer cells infiltrate breast cancer draining lymph nodes

Cancer Immunology Research; Año: 2018

TRUCCO, LUCAS DANIEL; ROSELLI, EMILIANO; ARAYA, PAULA; NUÑEZ, NICOLÁS GONZALO; MENA, HEBE AGUSTINA; BOCCO, JOSÉ LUIS; NEGROTTO, SOLEDAD; MACCIONI, MARIANA

Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma

PLOS ONE; Año: 2017 vol. 12

BARBARIN, ALICE; CAYSSIALS, EMILIE; JACOMET, FLORENCE; NUNEZ, NICOLAS GONZALO; BASBOUS, SARA; LEFÈVRE, LUCIE; ABDALLAH, MYRIAM; PICCIRILLI, NATHALIE; MORIN, BENJAMIN; LAVOUE, VINCENT; CATROS, VÉRONIQUE; PIAGGIO, ELIANE; HERBELIN, ANDRÉ; GOMBERT, JEAN-MARC

Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases

Frontiers in Immunology; Año: 2017 vol. 8

NOCERA, DAVID ANDRÉS; ROSELLI, EMILIANO; ARAYA, PAULA; NUÑEZ, NICOLÁS GONZALO; LIENENKLAUS, STEFAN; JABLONSKA, JADWIGA; WEISS, SIEGFRIED; GATTI, GERARDO; BRINKMANN, MELANIE M.; KRÖGER, ANDREA; MORÓN, GABRIEL; MACCIONI, MARIANA

In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid Administration

JOURNAL OF IMMUNOLOGY; Año: 2016 vol. 196 p. 2860 - 2869

PÉROL, LOUIS; LINDNER, JOHN M.; CAUDANA, PAMELA; NUNEZ, NICOLAS GONZALO; BAEYENS, AUDREY; VALLE, ANDREA; SEDLIK, CHRISTINE; LOIRAT, DELPHINE; BOYER, OLIVIER; CRÉANGE, ALAIN; COHEN, JOSÉ LAURENT; ROGNER, UTE CHRISTINE; YAMANOUCHI, JUN; MARCHANT, MARTINE; LEBER, XAVIER CHARLES; SCHARENBERG, MEIKE; GAGNERAULT, MARIE-CLAUDE; MALLONE, ROBERTO; BATTAGLIA, MANUELA; SANTAMARIA, PERE; HARTEMANN, AGNÈS; TRAGGIAI, ELISABETTA; PIAGGIO, ELIANE

Loss of immune tolerance to IL-2 in type 1 diabetes

NATURE COMMUNICATIONS; Año: 2016 vol. 7

ZACCA, ESTEFANÍA R.; CRESPO, MARÍA I.; ACLAND, RACHEL P.; ROSELLI, EMILIANO; NÚÑEZ, NICOLÁS G.; MACCIONI, MARIANA; MALETTO, BELKYS A.; PISTORESI-PALENCIA, MARÍA C.; MORÓN, GABRIEL

Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand

PLOS ONE; Año: 2015 vol. 10

TRUCCO, LUCAS DANIEL; ANDREOLI, VERÓNICA; NÚÑEZ, NICOLÁS GONZALO; MACCIONI, MARIANA; BOCCO, JOSÉ LUIS

Krüppel-like factor 6 interferes with cellular transformation induced by the H- ras oncogene

FASEB JOURNAL; Año: 2014 vol. 28 p. 5262 - 5276

CRESPO, M. I.; ZACCA, E. R.; NUNEZ, N. G.; RANOCCHIA, R. P.; MACCIONI, M.; MALETTO, B. A.; PISTORESI-PALENCIA, M. C.; MORON, G.

TLR7 Triggering with Polyuridylic Acid Promotes Cross-Presentation in CD8 + Conventional Dendritic Cells by Enhancing Antigen Preservation and MHC Class I Antigen Permanence on the Dendritic Cell Surface

JOURNAL OF IMMUNOLOGY; Año: 2013 vol. 190 p. 948 - 960

GATTI, GERARDO; NUÑEZ, NICOLÁS GONZALO; NOCERA, DAVID ANDRÉS; DEJAGER, LIEN; LIBERT, CLAUDE; GIRAUDO, CONSTANCIO; MACCIONI, MARIANA

Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-β production capable of improving dendritic cell function

EUROPEAN JOURNAL OF IMMUNOLOGY; Año: 2013 vol. 43 p. 1849 - 1861

NÚÑEZ NG, ANDREANI V, CRESPO MI, NOCERA DA, BRESER ML, MORÓN G, DEJAGER L, LIBERT C, RIVERO V, MACCIONI M.

IFNβ Produced by TLR4-Activated Tumor Cells Is Involved in Improving the Antitumoral Immune Response.

CANCER RESEARCH; Año: 2012 p. 592 - 603

CARRANZA F, FALCÓN C, NUÑEZ N, KNUBEL C, CORREA S, BIANCO S, MACCIONI M, FRETES R, TRIQUELL F, MOTRÁN C AND CERVI L.

Helminth antigens enable CpG-activated dendritic cells to inhibit the symptoms of collagen-induced arthritis through Foxp3+ regulatory T cells

PLOS ONE; Lugar: San Francisco; Año: 2012 p. 1 - 2

MACKERN OBERTI JP, BRESER ML, NUÑEZ N, MACCIONI M, RODRÍGUEZ N, WANTIA N, ERTL T, MIETHKE T, RIVERO VE.

Chemokine response induced by Chlamydia trachomatis in prostate derived CD45+ and CD45- cells.

REPRODUCTION; Año: 2011 p. 427 - 437

KOWALJOW V; MARCOWYCZ A; ANSSEAU E; CONDE CB; SAUVAGE S; MATTÉOTTI C; ARIAS C; CORONA ED; NUÑEZ NG; LEO O; WATTIEZ R; FIGLEWICZ D; LAOUDJ-CHENIVESSE D; BELAYEW A; COPPÉE F; ROSA AL

The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein

NEUROMUSCULAR DISORDERS; Año: 2007 vol. 17 p. 611 - 623