CONTRATADOS
GIULIETTI Ana Maria
congresos y reuniones científicas
Título:
Anisodamine production by Argentinean and Colombian Brugmansia candida
Autor/es:
CARDILLO, A.B.; OTALVARO A.M.; CALABRÓ LOPEZ A.; VELÁSQUEZ M.E.; RODRIGUEZ TALOU, J.; GIULIETTI, A.M.
Lugar:
Rosario
Reunión:
Congreso; REDBIO 2009; 2009
Resumen:
Brugmansia candida (syn Datura candida) is a South American native plant and a tropane alkaloid producer. Hyoscyamine (1) and scopolamine (3) are tropane alkaloids that were traditionally used as pharmaceuticals due to their anticholinergic activity. Nowadays, anisodamine (2) is gaining attention according to the wide range of therapeutical applications described for the alkaloid. The chemical synthesis of tropane alkaloids is complicated and time consuming. For this reason, their isolation from plants is still the strategy of choice. The use of in vitro cultures for large scale secondary metabolite production and recent progresses in the scaling-up of hairy root cultures are making this system an attractive tool for industrial processes.syn Datura candida) is a South American native plant and a tropane alkaloid producer. Hyoscyamine (1) and scopolamine (3) are tropane alkaloids that were traditionally used as pharmaceuticals due to their anticholinergic activity. Nowadays, anisodamine (2) is gaining attention according to the wide range of therapeutical applications described for the alkaloid. The chemical synthesis of tropane alkaloids is complicated and time consuming. For this reason, their isolation from plants is still the strategy of choice. The use of in vitro cultures for large scale secondary metabolite production and recent progresses in the scaling-up of hairy root cultures are making this system an attractive tool for industrial processes.in vitro cultures for large scale secondary metabolite production and recent progresses in the scaling-up of hairy root cultures are making this system an attractive tool for industrial processes.