CONTRATADOS
GIULIETTI Ana Maria
congresos y reuniones científicas
Título:
Biotransformation using recombinant microorganisms as a strategy for the production of pharmaceutical compounds
Autor/es:
ALEJANDRA CARDILLO; JULIÁN RODRÍGUEZ TALOU; ANA MARIA GIULIETTI
Reunión:
Congreso; VII Workshop on Biocatalysis and Biotransformations -1 Simposio Latinoamericano de Biocatálisis y Biotransformaciones; 2014
Resumen:
Hyoscyamine, 6b-hydroxyhyoscyamine and scopolamine are tropane alkaloids that were traditionally applied in medicine according to their anticholinergic activity. Hyoscyamine is converted by Hyoscyamine-6?Ò-hydroxylase (H6H) into the most valuable alkaloids, 6b-hydroxyhyoscyamine and scopolamine [1].   Nowadays, these bioactive compounds are obtained from producer plants due to the cost and complexity of their chemical synthesis. For this reason, its production by biotransformation is an attractive strategy for the pharmaceutical industry [2].   In this work we explored the production of tropane alkaloids using recombinant yeast and bacteria harboring the H6H enzyme as biocatalyst.