INVESTIGADORES
MURRAY Ana Paula
congresos y reuniones científicas
Título:
Essential oil from fruits and leaves of Schinus areira L. with acetylcholinesterase inhibitory activity
Autor/es:
VELA GUROVIC, MARÍA SOLEDAD; ANA PAULA MURRAY; ADRIANA FERRERO
Lugar:
Graz, Austria
Reunión:
Congreso; 55th International Congress and Annual Meeting of the Society for Medicinal Plant Research; 2007
Institución organizadora:
Society for Medicinal Plant Research
Resumen:
Currently available drugs for the symptomatic treatment of Alzheimer´s disease (AD) are based on the inhibition of the enzyme acetylcholinesterase (AChE). Recently, essential oils as well as terpenoids have been shown to inhibit AChE in in vitro assays [1], [2]. In the present communication we are reporting the evaluation of the essential oils from fruits and leaves of Schinus areira L (Anacardiaceae), extensively used in folk medicine in South America [3], for their activity towards AChE. The enzymatic activity was evaluated using an adaptation of a previously described method [4]. The composition of the essential oils was determined by GC and GC-MS [5]. The essential oil from fruits showed a 29.00±4.84% AChE inhibition while the essential oil from leaves showed a 13.67±0.67% AChE inhibition under the same conditions (0.1µL/mL). Chromatographic fractionation of the essential oils guided by the bioassay led to the isolation of the active fractions. GC-MS analysis of those fractions revealed the presence of sesquiterpenes like â-eudesmol and elemol, which have been reported as compounds that may have potential therapeutic use against amnesia-inducing diseases like AD [6], [7].
Acknowledgements: CONICET, ANPCYT, SECYT-UNS.
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