Tailored Multi-target Agents. Applications and Design Considerations

ALAN TALEVI

CURRENT PHARMACEUTICAL DESIGN.

BENTHAM SCIENCE PUBL LTD

Lugar: Oak Park; Año: 2016 vol. 22 p. 3164 - 3170

1381-6128

In contrast to the one target-one drug model, multi-target agents seem as a promising alternative to manage complex disorders and health conditions linked to drug resistance issues. In fact, many longstanding drugs are in fact unintended multi-functional therapeutics that have emerged from phenotypic models. The last two decades, however, have witnessed the emergence of tailored multi-target agents, which according to our perspective combine the best aspects of target-based and phenotypic-based drug discovery. Here we discuss a number of considerations related to the design, screening and computer-aided discovery of multi-targeted drugs, along with neglected advantages that this type of agents might have in clinical trials.