Studies of ciprofloxacin encapsulation on biogels in organic solvent mixture.

V. E. BOSIO; G.A. ISLAN; GR CASTRO

BOSTON

Congreso; 24oth American Chemical Society National Meeting & Exposition.; 2010

ACS

Current oral administration of ciprofloxacin antibiotic is commonly associated to gastric and intestinal issues. Besides, ciprofloxacin has tendency to stacking with reduced biodisponibility. Encapsulation of the antibiotic on biogels, like alginates, is an alternative for oral delivery. However, ciprofloxacin encapsulation on alginate (2.0 %) microspheres (600 μm diameter) yield is about 46 % under physiological aqueous conditions. Alternatively, biocompatible miscible organic aqueous (O-A) solvent mixtures can increase the encapsulation considering the low solubility of the drug. 1,2 polypropilenglycol and High Methoxyl degree pectin were tested to delay ciprofloxacin release under simulated gastric fluid (pH=1.2) and to increase the drug liberation at the intestinal simulated fluid (pH=7,4).