INVESTIGADORES
JAWERBAUM Alicia Sandra
artículos
Título:
Inhibition of MTOR signaling impairs rat embryo organogenesis by affecting folate availability
Autor/es:
HIGA, ROMINA; ROSARIO, FREDRICK J; POWELL, THERESA L; JANSSON, THOMAS; JAWERBAUM, ALICIA
Revista:
REPRODUCTION
Editorial:
BIOSCIENTIFICA LTD
Referencias:
Año: 2021 vol. 161 p. 365 - 373
ISSN:
1470-1626
Resumen:
Mechanistic target of rapamycin (mTOR) is essential for embryo development by acting as a nutrient sensor to regulate cell growth, proliferation and metabolism. Folate is required for embryonic ribosomal protein S6, a downstream target of mTOR Complex1, markedly reduced embryonic folate incorporation (-84%, p
