Modulatory effect of leptin on nitric oxide production and lipid metabolism in term placental tissues from control and streptozotocin-induced rats

WHITE V, GONZÁLEZ E, CAPOBIANCO E, PUSTOVRH MC, SOÑEZ C, ROMANINI MC, JAWERBAUM A

REPRODUCTION FERTILITY AND DEVELOPMENT

CSIRO

Lugar: Australia; Año: 2004 vol. 16 p. 363 - 372

1031-3613

Leptin production by placental tissues contributes to its circulating levels andfunctions. The diabetic pathology induces alterations in leptin levels. In thepresent study, leptin levels were evaluated in placental tissue from control andneonatal streptozotocin-induced (n-STZ) diabetic rats during late gestation. Theeffects of leptin levels on the generation of nitric oxide (NO), prostaglandin(PG) E(2) production and lipid metabolism were examined. Leptin levels werediminished in placentas from n-STZ diabetic rats compared with controls (P