INVESTIGADORES
COINTRY Gustavo Roberto
congresos y reuniones científicas
Título:
Tomographical (pQCT) indicators of bone size, mass, mineralization, design and strength, and of muscle strength, in weight-bearing and non weight-bearing bones in men and women. Reference data, normal associations, and original software for individual Z-s
Autor/es:
RICARDO FRANCISCO CAPOZZA; GUSTAVO ROBERTO COINTRY; SARA FELDMAN; SEBASTIAN EDUARDO FERRETTI; PAOLA REINA; PABLO ANDRÉS MORTARINO; BRENDA HOMSE; MARIANO ZAPATA; MARIO MOROSANO; ANA MASSONI; ROBERTO TOZZINI; JOSÉ LUIS FERRETTI
Lugar:
Colonia (Alemania)
Reunión:
Workshop; VI INTERNATIONAL WORKSHOP FOR MUSCULOSKELETAL & NEURONAL INTERACTIONS; 2008
Institución organizadora:
International Society of Musculoskeletal & Neuronal Interactions (ISMNI)
Resumen:
pQCT ASSESSMENT OF MUSCULOSKELETAL STATUS IN NORMAL HUMANS - I. RELATIONSHIPS BETWEEN BONE MASS, MINERALIZATION, DESIGN OR STRENGTH INDICATORS AND AGE, MENOAGE OR MUSCLE MASS.  Capozza RF,  Cointry GR, Feldman S, Ferretti SE, Lipsitz A, Ivancich G, Marchetti G, Ferretti MV, Ferretti JL. Center for P-Ca Metabolism Studies (CEMFoC), Natl. Univ. of Rosario, Argentina.   A standardization of methods, sites, variables, data management, analyses and interpretation of pQCT determinations is urgently required. Aiming to offer some reference for that purpose,  pQCT indicators of bone mass (total, cortical and trabecular BMC, cortical CSA, trabecular vBMD), mineralization (cortical vBMD), design (CSMI’s), and strength (BSI’s, pSSI), and muscle CSA (MCSA) were determined in forerarms (4% and 66% sites) and legs (4%, 14%, 38%, and 66% sites) of 250 normal volunteers (40 men, 60 pre-MP women, 150 post-MP women) aged 20-86 years. Correlations of every bone indicator with age, menoage and MCSA were analyzed. A specially-developed software allowed 1. massive storage and analysis of data employing single databases, Z-scorization of any obtained correlation curve, and individual Z-score calculation, specifically for gender and reproductive status. Little or no correlation of bone data with age was observed in men and pre-MP women. Some significant, negative influence of menoage on bone variables was detected, with decreasing significance for mineralization > mass > strength > design indicators. Highly significant, linear correlations between bone mass, design and strength indicators (tibial 38% site, radial 66% site, y) and MCSA (66% sites, x) were observed for men and pre-MP women together. The relationship between cortical [tibia+fibula] CSA and MCSA showed a 0.05 slope comprising the origin, as predicted by biomechanical considerations. Plotted on the Z-scored charts of the muscle-bone relationships for pre-MP women, post-MP women data shifted significantly to the lower-right regions. Negative associations between the Z-scores of these relationships for post-MP women and menoage were observed for bone mass and strength (not design) indicators. Results show that regional muscle strength influences bone mass, design and strength more significantly than age or menoage. A larger negative influence of menoage on cortical mineralization than on diaphyseal design was observed, suggesting the persistence of some directional control of cortical modeling by bone mechanostat after MP. However, this would have not compensated for the progressive loss of cortical vBMD (stiffness) and strength. The obtained Z-scored graphs of the muscle-bone relationships provide suitable references for a differential diagnosis between mechanical and metabolic osteopenias according to previously defined criteria.