COLMAN LERNER Alejandro Ariel
Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition
ANDREAS DONCIC; OGUZHAN ATAY; ERVIN VALK; ALICIA GRANDE; ALAN BUSH; GUSTAVO VASEN; ALEJANDRO COLMAN LERNER; MART LOOG; JAN SKOTHEIM
Lugar: United States; Año: 2015 vol. 120
Cells make accurate decisions in the face of molecu- lar noise and environmental fluctuations by relying not only on present pathway activity, but also on their memory of past signaling dynamics. Once a decision is made, cellular transitions are often rapid and switch-like due to positive feedback loops in the reg- ulatory network. While positive feedback loops are good at promoting switch-like transitions, they are not expected to retain information to inform subse- quent decisions. However, this expectation is based on our current understanding of network motifs that accounts for temporal, but not spatial, dynamics. Here, we show how spatial organization of the feed- back-driven yeast G1/S switch enables the transmis- sion of memory of past pheromone exposure across this transition. We expect this to be one of many ex- amples where the exquisite spatial organization of the eukaryotic cell enables previously well-charac- terized network motifs to perform new and unex- pected signal processing functions.