Molecular evolution of transition metal bioavailability at the host-pathogen interface

GIULIANO TOMAS ANTELO; ALEJANDRO VILA; GIEDROC, DAVID P; CAPDEVILA, DAIANA A

TRENDS IN MICROBIOLOGY

ELSEVIER SCIENCE LONDON

Lugar: Londres; Año: 2020

0966-842X

Molecular evolution of the adaptive response at the host-pathogen interface has beenfrequently referred to as an ?arms race? between the host and bacterial pathogens. Theinnate immune system employs multiple strategies to starve microbes for metals.Pathogens, in turn, develop successful strategies to maintain access to bioavailablemetal ions under conditions of extreme transition metal restriction, or nutritionalimmunity. However, the processes by which evolution repurposes or re-engineers hostand pathogen proteins to perform new functions have been explored only recently. Themolecular evolution of calgranulins, transition metal-chelating S100 proteins, arediscussed, as is the coevolution of human transferrin and bacterial transition metalacquisition systems and the biological specificity in regulatory proteins tasked withmaintaining metallostasis. Finally, the evolution of metallo-β-lactamases, obligatoryzinc metalloenzymes, provides an illustration of how rapid evolution derived fromantibiotic stress occurs in the context of host-directed nutritional immunity.